HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	15707590, 12029088
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 665
+	Hs
		523104 SRC_HUMAN (1-524): 0: 582: 54.51		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		411817 LCK_HUMAN (23-526): 0: 581: 64.89		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		412296 FYN_HUMAN (22-524): 0: 564: 57.79		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		442898 HCK_HUMAN (1-526): 0: 635: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		433938 LYN_HUMAN (22-526): 0: 554: 70.70		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		454842 FGR_HUMAN (22-524): 0: 552: 55.62		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		412426 FYN_HUMAN (22-524): 0: 564: 57.79		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		523022 SRC_HUMAN (1-524): 0: 582: 54.51		SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72
+	Hs
		522887 SRC_HUMAN (1-524): 0: 582: 54.51		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		411986 FYN_HUMAN (22-524): 0: 564: 57.79		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Mm
		763403 FYN_MOUSE (22-524): 0: 564: 57.60		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Mm
		763393 FYN_MOUSE (22-524): 0: 564: 57.60		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		411580 LCK_HUMAN (23-526): 0: 581: 64.89		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		433781 LYN_HUMAN (22-526): 0: 554: 70.70		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Ce
		220205 SRC2_CAEEL (23-524): 0: 524: 46.65		SEM5_CAEEL (2-167): 1.56e-29: 118: 21.08
+	Hs
		411981 FYN_HUMAN (22-524): 0: 564: 57.79		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		433859 LYN_HUMAN (22-526): 0: 554: 70.70		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Hs
		433807 LYN_HUMAN (22-526): 0: 554: 70.70		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31
+	Hs
		209001 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		235483 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82