HitPredict

Interactor 1: PRGR (P06401)
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene: PGR

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11117529
Identification Methods	biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding GO:0010629 - negative regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 933 Hs			1 628
+	Hs
		520494 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		1367728 ESR2_HUMAN (453-926): 3.09e-91: 301: 22.80		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		397353 ESR1_HUMAN (436-917): 2.06e-89: 298: 22.00		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		297403 PRGR_HUMAN (1-933): 5.59e-132: 421: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297735 PRGR_HUMAN (1-933): 5.59e-132: 421: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		297394 GCR_HUMAN (256-933): 7.42e-99: 329: 33.53		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297418 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297594 NR1H3_HUMAN (473-916): 1.46e-95: 310: 20.97		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297661 ESR2_HUMAN (453-926): 3.09e-91: 301: 22.80		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297393 ESR1_HUMAN (436-917): 2.06e-89: 298: 22.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297495 HNF4A_HUMAN (567-919): 1.24e-82: 276: 22.60		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297732 GCR_HUMAN (256-933): 7.42e-99: 329: 33.53		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		297739 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		297843 ESR2_HUMAN (453-926): 3.09e-91: 301: 22.80		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		297731 ESR1_HUMAN (436-917): 2.06e-89: 298: 22.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		520201 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71
+	Hs
		543584 ERR1_HUMAN (496-855): 3.7e-96: 311: 27.50		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71
+	Hs
		833992 HNF4A_HUMAN (567-919): 1.24e-82: 276: 22.60		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71
+	Hs
		520443 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		ZMIZ1_HUMAN (79-422): 1.83e-84: 287: 24.93
+	Hs
		520208 ANDR_HUMAN (122-933): 6.55e-96: 324: 30.41		ZMIZ2_HUMAN (81-619): 2.54e-79: 271: 20.46