HitPredict

Interactor 1: STE7 (P06784)
Serine/threonine-protein kinase STE7 (EC 2.7.12.2)
Gene: STE7

Interactor 2: KSS1 (P14681)
Mitogen-activated protein kinase KSS1 (MAP kinase KSS1) (EC 2.7.11.24) (Kinase suppressor of SST2)
Gene: KSS1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 10688190, 7851759, 8668180, 11283351, 11805837, 11525741, 15456892, 20489023, 21118957, 14734536, 11134045, 16364919, 18077328, 19303851, 23953117, 8062390
Identification Methods two hybrid, affinity chromatography technology, two hybrid pooling approach, coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, protein complementation assay, unspecified method, fluorescent resonance energy transfer, enzymatic study and 2 others

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Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000749 - response to pheromone triggering conjugation with cellular fusion
GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001402 - signal transduction involved in filamentous growth
GO:0001403 - invasive growth in response to glucose limitation
GO:0004674 - protein serine/threonine kinase activity
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 515
Sc

1 368
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+ Mm
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Service provided by Combinatics, Japan

Last updated: 11Aug2025