Protein: FUS3
Mitogen-activated protein kinase FUS3 (MAP kinase FUS3) (EC 2.7.11.24)

Gene: FUS3
Organism: Saccharomyces cerevisiae S288C
Interactions: 146
UniProt ID: P16892

Gene Ontology (top 5):
GO:0000749 - response to pheromone triggering conjugation with cellular fusion
GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001403 - invasive growth in response to glucose limitation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

599339

STE5
Protein STE5

23

1

Small-scale

0.990

High

448850

STE7
Serine/threonine-protein kinase STE7

21

20

Small-scale

0.990

High

599327

STE11
Serine/threonine-protein kinase STE11

7

16

Small-scale

0.953

High

599351

MSG5
Tyrosine-protein phosphatase MSG5

5

20

Small-scale

0.922

High

599315

FUS3
Mitogen-activated protein kinase FUS3

4

19

Small-scale

0.894

High

599365

PTP3
Tyrosine-protein phosphatase 3

2

17

Small-scale

0.838

High

599352

RCK1
Serine/threonine-protein kinase RCK1

2

17

High-throughput

0.789

High

599395

DIG2
Down-regulator of invasive growth 2

9

1

Small-scale

0.757

High

574626

KSS1
Mitogen-activated protein kinase KSS1

2

17

Small-scale

0.743

High

599393

DIG1
Down-regulator of invasive growth 1

6

1

Small-scale

0.742

High

599316

TEC1
Ty transcription activator TEC1

4

2

Small-scale

0.700

High

452709

ADR1
Regulatory protein ADR1

1

1

High-throughput

0.691

High

599347

BOI1
BEM1-interacting protein 1

1

8

High-throughput

0.691

High

599389

CDC14
Tyrosine-protein phosphatase CDC14

1

20

High-throughput

0.691

High

470731

GPA1
Guanine nucleotide-binding protein alpha-1 subunit

3

3

Small-scale

0.670

High

599324

FAR1
Cyclin-dependent kinase inhibitor FAR1

4

0

Small-scale

0.666

High

564638

STE12
Protein STE12

3

2

Small-scale

0.664

High

548664

RNA1
Ran GTPase-activating protein 1

1

4

High-throughput

0.647

High

550567

SST2
Protein SST2

1

1

Small-scale

0.647

High

578785

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.647

High

599321

FKBP
FK506-binding protein 1

1

6

High-throughput

0.647

High

599325

KCC2
Calcium/calmodulin-dependent protein kinase II

1

18

High-throughput

0.647

High

599386

JJJ1
J protein JJJ1

1

7

High-throughput

0.647

High

599421

ARP8
Actin-like protein ARP8

1

8

High-throughput

0.647

High

448633

SNF1
Carbon catabolite-derepressing protein kinase

1

2

Small-scale

0.621

High

599409

RGC1
Regulator of the glycerol channel 1

2

3

High-throughput

0.619

High

599364

BOI2
BEM1-interacting protein 2

1

7

High-throughput

0.618

High

599390

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

5

Small-scale

0.602

High

599332

TF2B
Transcription initiation factor IIB

2

8

High-throughput

0.595

High

590519

HSP26
Heat shock protein 26

2

3

High-throughput

0.588

High

599320

HSP60
Heat shock protein 60, mitochondrial

2

9

High-throughput

0.588

High

599420

HSP42
Heat shock protein 42

2

3

High-throughput

0.588

High

416854

CDC25
Cell division control protein 25

1

3

Small-scale

0.578

High

599361

MPT5
Suppressor protein MPT5

1

1

Small-scale

0.573

High

558563

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.569

High

599415

ALR1
Magnesium transporter ALR1

2

1

High-throughput

0.565

High

599358

KEL1
Kelch repeat-containing protein 1

1

5

Small-scale

0.561

High

599362

RV167
Reduced viability upon starvation protein 167

1

2

Small-scale

0.536

High

599335

XPO1
Exportin-1

1

3

High-throughput

0.536

High

599341

BCK2
Protein BCK2

1

1

High-throughput

0.536

High

599379

ASK10
Activator of SKN7 protein 10

1

3

High-throughput

0.536

High

599385

VPS75
Vacuolar protein sorting-associated protein 75

1

4

High-throughput

0.515

High

599353

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.513

High

599377

NET1
Nucleolar protein NET1

1

0

High-throughput

0.513

High

599396

YM8V
Uncharacterized protein YMR295C

1

0

High-throughput

0.513

High

599397

NAB6
RNA-binding protein NAB6

1

0

High-throughput

0.513

High

368317

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

4

High-throughput

0.501

High

381851

H4
Histone H4

1

2

Small-scale

0.501

High

419348

H2A1
Histone H2A.1

1

3

High-throughput

0.501

High

470452

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.501

High

473513

LEUR
Regulatory protein LEU3

1

3

High-throughput

0.501

High

504585

YH11A
Transposon Ty1-H Gag polyprotein

1

8

High-throughput

0.501

High

514926

YA11A
Transposon Ty1-A Gag polyprotein

1

10

High-throughput

0.501

High

514961

YP13A
Transposon Ty1-PR2 Gag polyprotein

1

9

High-throughput

0.501

High

514987

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

8

High-throughput

0.501

High

584883

TRM1
tRNA

1

2

High-throughput

0.501

High

599319

PRP6
Pre-mRNA-splicing factor 6

1

2

High-throughput

0.501

High

599328

MCM3
DNA replication licensing factor MCM3

1

10

High-throughput

0.501

High

599329

IF2M
Translation initiation factor IF-2, mitochondrial

1

6

High-throughput

0.501

High

599330

PTP1
Tyrosine-protein phosphatase 1

1

14

Small-scale

0.501

High

599334

MCM2
DNA replication licensing factor MCM2

1

10

High-throughput

0.501

High

599336

RML2
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.501

High

599342

YBF5
Deoxyribonuclease Tat-D

1

1

High-throughput

0.501

High

599345

EF1G2
Elongation factor 1-gamma 2

1

6

High-throughput

0.501

High

599355

APM2
Adaptin medium chain homolog APM2

1

2

High-throughput

0.501

High

599356

TOM71
Protein TOM71

1

3

High-throughput

0.501

High

599363

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

2

High-throughput

0.501

High

599372

ELP2
Elongator complex protein 2

1

6

High-throughput

0.501

High

599373

BUD27
Bud site selection protein 27

1

1

High-throughput

0.501

High

599387

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

5

High-throughput

0.501

High

599391

MTD1
Methylenetetrahydrofolate dehydrogenase [NAD(+)]

1

2

High-throughput

0.501

High

599403

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.501

High

599404

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

9

High-throughput

0.501

High

599413

BDF2
Bromodomain-containing factor 2

1

12

High-throughput

0.501

High

599417

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

9

High-throughput

0.501

High

599418

SAS10
Something about silencing protein 10

1

1

High-throughput

0.501

High

599422

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

7

High-throughput

0.501

High

599423

YD21A
Transposon Ty2-DR1 Gag polyprotein

1

9

High-throughput

0.501

High

599424

YN12A
Transposon Ty1-NL2 Gag polyprotein

1

9

High-throughput

0.501

High

599426

YP14A
Transposon Ty1-PR3 Gag polyprotein

1

8

High-throughput

0.501

High

599427

YO11A
Transposon Ty1-OL Gag polyprotein

1

8

High-throughput

0.501

High

599318

RDS2
Regulator of drug sensitivity 2

1

0

High-throughput

0.480

High

599331

FUN19
SWIRM domain-containing protein FUN19

1

0

High-throughput

0.480

High

599338

TIM12
Mitochondrial import inner membrane translocase subunit TIM12

1

0

High-throughput

0.480

High

599343

PTH2
Peptidyl-tRNA hydrolase 2

1

0

High-throughput

0.480

High

599357

YHT1
PH domain-containing protein YHR131C

1

0

High-throughput

0.480

High

599360

LYS9
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

1

0

High-throughput

0.480

High

599370

BNI1
Protein BNI1

1

0

Small-scale

0.480

High

599378

DENR
Translation machinery-associated protein 22

1

0

High-throughput

0.480

High

599380

GYP3
GTPase-activating protein GYP3

1

0

High-throughput

0.480

High

599381

YG51
Uncharacterized protein YGR237C

1

0

High-throughput

0.480

High

599382

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.480

High

599383

YGI2
Uncharacterized protein YGL082W

1

0

High-throughput

0.480

High

599388

EAF7
Chromatin modification-related protein EAF7

1

0

High-throughput

0.480

High

599392

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.480

High

599398

GIR2
Protein GIR2

1

0

High-throughput

0.480

High

599399

ENT5
Epsin-5

1

0

High-throughput

0.480

High

599400

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.480

High

599402

LRS4
Monopolin complex subunit LRS4

1

0

High-throughput

0.480

High

599405

HEL2
E3 ubiquitin-protein ligase HEL2

1

0

High-throughput

0.480

High

599407

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.480

High

599412

LOA1
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

1

0

High-throughput

0.480

High

599414

CMS1
Protein CMS1

1

0

High-throughput

0.480

High

599416

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.480

High

599425

PAR32
Protein PAR32

1

0

High-throughput

0.480

High

358960

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

5

High-throughput

0.479

High

533154

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

2

Small-scale

0.479

High

599323

PSA7
Probable proteasome subunit alpha type-7

1

4

High-throughput

0.479

High

599326

SPA2
Protein SPA2

1

8

Small-scale

0.479

High

599333

BEM1
Bud emergence protein 1

1

2

Small-scale

0.479

High

599340

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

599371

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.479

High

599374

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

6

High-throughput

0.479

High

439227

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

455475

PMM
Phosphomannomutase

1

0

High-throughput

0.458

High

599369

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

599401

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

599410

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

408548

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.457

High

409914

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.457

High

599344

MNR2
Manganese resistance protein MNR2

1

1

High-throughput

0.457

High

599346

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

1

High-throughput

0.457

High

599354

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

5

High-throughput

0.457

High

599366

UTP7
U3 small nucleolar RNA-associated protein 7

1

3

High-throughput

0.457

High

599411

RGA2
Rho-type GTPase-activating protein 2

1

8

Small-scale

0.457

High

548257

FUS1
Nuclear fusion protein FUS1

1

1

Small-scale

0.457

High

599317

GBB
Guanine nucleotide-binding protein subunit beta

1

9

Small-scale

0.457

High

599359

MTG2
GTPase MTG2, mitochondrial

1

4

High-throughput

0.457

High

522966

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

525844

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

543721

SSB1
Ribosome-associated molecular chaperone SSB1

1

13

High-throughput

0.445

High

599367

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

599394

SDC1
COMPASS component SDC1

1

0

High-throughput

0.438

High

599406

FUS2
Nuclear fusion protein FUS2

1

0

Small-scale

0.438

High

599419

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

599368

CSS1
Secreted protein CSS1

1

4

High-throughput

0.417

High

599322

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.261

Low

599337

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

0

High-throughput

0.261

Low

599349

YB9F
Uncharacterized protein YBR259W

1

0

High-throughput

0.261

Low

599350

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

0

High-throughput

0.261

Low

599375

OSW7
Outer spore wall protein 7

1

0

High-throughput

0.261

Low

599376

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.261

Low

599384

ARE2
Sterol O-acyltransferase 2

1

0

High-throughput

0.261

Low

599408

CST9
Chromosome stability protein 9

1

0

High-throughput

0.261

Low

599348

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025