HitPredict

Interactor 1: ENPL (P08110)
Endoplasmin (EC 3.6.4.-) (Heat shock 108 kDa protein) (HSP 108) (HSP108) (Heat shock protein 90 kDa beta member 1) (Transferrin-binding protein)
Gene: HSP90B1

Interactor 2: BRAF (Q04982)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (Proto-oncogene c-Rmil) (Serine/threonine-protein kinase Rmil)
Gene: BRAF

Species: Gallus gallus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27034005
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 795 Gg			1 766
+	Hs
		573306 ENPL_HUMAN (1-795): 0: 1038: 89.04		BRAF_HUMAN (1-766): 0: 748: 93.89
+	Mm
		465806 ENPL_MOUSE (1-782): 0: 1033: 89.66		BRAF_MOUSE (9-766): 0: 708: 89.34
+	Hs
		468028 HS90B_HUMAN (74-776): 0: 975: 46.54		BRAF_HUMAN (1-766): 0: 748: 93.89
+	Hs
		461106 HS90A_HUMAN (63-776): 0: 967: 45.73		BRAF_HUMAN (1-766): 0: 748: 93.89
+	Hs
		400224 ENPL_HUMAN (1-795): 0: 1038: 89.04		RAF1_HUMAN (100-755): 0: 562: 54.17
+	Hs
		400147 HS90B_HUMAN (74-776): 0: 975: 46.54		RAF1_HUMAN (100-755): 0: 562: 54.17
+	Hs
		400141 HS90A_HUMAN (63-776): 0: 967: 45.73		RAF1_HUMAN (100-755): 0: 562: 54.17
+	Hs
		521184 ENPL_HUMAN (1-795): 0: 1038: 89.04		ARAF_HUMAN (143-750): 2.49e-163: 487: 56.05
+	Hs
		467998 HS90B_HUMAN (74-776): 0: 975: 46.54		ARAF_HUMAN (143-750): 2.49e-163: 487: 56.05
+	Hs
		461178 HS90A_HUMAN (63-776): 0: 967: 45.73		EPHA3_HUMAN (91-752): 2.22e-160: 492: 18.12
+	Hs
		468217 HS90B_HUMAN (74-776): 0: 975: 46.54		EPHB1_HUMAN (111-747): 3.03e-157: 484: 18.40
+	Hs
		461065 HS90A_HUMAN (63-776): 0: 967: 45.73		ARAF_HUMAN (143-750): 2.49e-163: 487: 56.05
+	Hs
		461310 HS90A_HUMAN (63-776): 0: 967: 45.73		EPHB1_HUMAN (111-747): 3.03e-157: 484: 18.40
+	Hs
		468218 HS90B_HUMAN (74-776): 0: 975: 46.54		EPHA4_HUMAN (79-747): 9.1e-153: 472: 18.79
+	Hs
		461311 HS90A_HUMAN (63-776): 0: 967: 45.73		EPHA4_HUMAN (79-747): 9.1e-153: 472: 18.79
+	Hs
		468066 HS90B_HUMAN (74-776): 0: 975: 46.54		EPHA1_HUMAN (120-757): 3.38e-132: 418: 18.93
+	Hs
		461145 HS90A_HUMAN (63-776): 0: 967: 45.73		EPHA1_HUMAN (120-757): 3.38e-132: 418: 18.93
+	Hs
		468570 HS90B_HUMAN (74-776): 0: 975: 46.54		KSR1_HUMAN (232-732): 9.27e-112: 362: 25.44
+	Hs
		468515 HS90B_HUMAN (74-776): 0: 975: 46.54		KSR2_HUMAN (449-731): 1.2e-46: 181: 36.52
+	Hs
		461612 HS90A_HUMAN (63-776): 0: 967: 45.73		KSR2_HUMAN (449-731): 1.2e-46: 181: 36.52