HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	21689689
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 551
+	Hs
		468053 HS90B_HUMAN (1-724): 0: 1083: 100.00		RO52_HUMAN (1-535): 5.75e-94: 297: 13.47
+	Hs
		461134 HS90A_HUMAN (1-724): 0: 1069: 85.25		RO52_HUMAN (1-535): 5.75e-94: 297: 13.47
+	Hs
		468773 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRIM6_HUMAN (1-521): 3.85e-88: 282: 13.03
+	Hs
		468772 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRIM7_HUMAN (10-512): 3.07e-74: 246: 14.63
+	Hs
		467994 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRI49_HUMAN (1-510): 1.33e-74: 245: 14.43
+	Hs
		461904 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRIM7_HUMAN (10-512): 3.07e-74: 246: 14.63
+	Hs
		461062 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRI49_HUMAN (1-510): 1.33e-74: 245: 14.43
+	Hs
		186497 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRI18_HUMAN (6-463): 1.77e-70: 240: 17.00
+	Hs
		468774 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRIM2_HUMAN (3-459): 3.82e-60: 213: 14.29
+	Hs
		468956 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRI17_HUMAN (2-522): 6.72e-62: 213: 14.42
+	Hs
		468830 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRI36_HUMAN (7-347): 2.62e-58: 208: 21.83
+	Hs
		461905 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRIM2_HUMAN (3-459): 3.82e-60: 213: 14.29
+	Hs
		462085 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRI17_HUMAN (2-522): 6.72e-62: 213: 14.42
+	Hs
		461957 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRI36_HUMAN (7-347): 2.62e-58: 208: 21.83
+	Hs
		461903 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRIM9_HUMAN (45-397): 8.72e-50: 184: 16.30
+	Hs
		468745 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRI56_HUMAN (13-261): 3.99e-42: 163: 26.64
+	Hs
		468771 HS90B_HUMAN (1-724): 0: 1083: 100.00		TRI31_HUMAN (1-313): 2.34e-41: 156: 19.11
+	Hs
		461877 HS90A_HUMAN (1-724): 0: 1069: 85.25		TRI56_HUMAN (13-261): 3.99e-42: 163: 26.64
+	Hs
		65477 ENPL_HUMAN (3-693): 0: 914: 46.44		TRI64_HUMAN (1-510): 7.42e-82: 264: 14.06
+	Hs
		573523 ENPL_HUMAN (3-693): 0: 914: 46.44		TRI68_HUMAN (1-512): 4.38e-77: 253: 12.29