HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBAC1 (Q9BSL1)
Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2)
Gene: UBAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	32296183, 28190767, 31494268, 38803224, unassigned1304
Identification Methods	two hybrid, pull down, unspecified method, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UBA~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 405
+	Hs
		476145 UBC_HUMAN (1-685): 0: 846: 100.00		UBP13_HUMAN (168-335): 1.26e-43: 164: 24.59
+	Hs
		475461 UBC_HUMAN (1-685): 0: 846: 100.00		UBP5_HUMAN (168-326): 1.36e-40: 155: 21.62
+	Hs
		475650 UBC_HUMAN (1-685): 0: 846: 100.00		UBXN1_HUMAN (191-276): 1.79e-20: 92.6: 37.50
+	Hs
		924140 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBAC1_HUMAN (1-405): 0: 579: 100.00
+	Mm
		476931 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBAC1_MOUSE (1-405): 0: 574: 88.75
+	Hs
		475168 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		UBAC1_HUMAN (1-405): 0: 579: 100.00
+	Sc
		477245 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP14_YEAST (170-328): 2.88e-16: 82.9: 18.13
+	At
		1091780 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP14_ARATH (168-328): 5.44e-33: 133: 20.99
+	Hs
		800571 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBP5_HUMAN (168-326): 1.36e-40: 155: 21.62
+	Mm
		476806 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP13_MOUSE (168-335): 5.27e-44: 165: 20.77
+	Rn
		88579 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3ZDI9_RAT (168-335): 2.99e-41: 157: 20.22
+	Rn
		88803 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3ZVQ0_RAT (168-326): 2.42e-41: 157: 21.62
+	Mm
		476724 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP5_MOUSE (168-326): 1.11e-40: 155: 21.62
+	Hs
		397832 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		UBP5_HUMAN (168-326): 1.36e-40: 155: 21.62
+	Hs
		474951 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		UBP5_HUMAN (168-326): 1.36e-40: 155: 21.62
+	Mm
		880545 ISG15_MOUSE (231-380): 3e-20: 90.1: 33.78		UBP5_MOUSE (168-326): 1.11e-40: 155: 21.62
+	Mm
		476957 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBXN1_MOUSE (191-276): 2.16e-19: 89.5: 36.46
+	Hs
		397924 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		UBXN1_HUMAN (191-276): 1.79e-20: 92.6: 37.50