HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	27182664, 35271311, 34642328, 35027744, 37071682, 11916981, 9857030, 23105008, 25799589, 30336976, 32101714, 33576509, 24361330, 38803224, 16868077, 20826778, 21281599, 22496338, 16007098, 24882218 and 1 others more... 24912152
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, cross-linking study, enzymatic study, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 200
+	Hs
		475501 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74
+	Hs
		476604 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74
+	Hs
		476218 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E2_HUMAN (3-153): 3.57e-68: 208: 40.40
+	Hs
		476155 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40
+	Hs
		475485 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2A_HUMAN (1-151): 4.98e-67: 203: 30.46
+	Hs
		475504 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E1_HUMAN (3-153): 1.87e-66: 203: 39.74
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (1-151): 3.09e-66: 202: 30.46
+	Hs
		475552 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2N_HUMAN (27-153): 1.06e-37: 129: 51.97
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (4-154): 7.76e-75: 223: 41.06
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (4-154): 2.12e-74: 222: 41.72
+	Dr
		94560 F1QHN6_DANRE (229-685): 0: 555: 99.78		Q7T3F3_DANRE (43-154): 5.67e-39: 132: 57.14
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (1-153): 6.39e-73: 218: 41.83
+	Sc
		477123 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC1_YEAST (6-153): 2.31e-48: 158: 50.34
+	At
		715116 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC8_ARATH (4-155): 1.43e-74: 222: 41.45
+	At
		715157 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC11_ARATH (4-155): 3.76e-74: 222: 42.11
+	At
		715132 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC9_ARATH (4-155): 4.47e-74: 221: 42.11
+	At
		715147 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC10_ARATH (4-155): 6.01e-74: 221: 41.45
+	At
		639385 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC1_ARATH (1-151): 3.62e-67: 204: 32.45