HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21512573
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_UBOX
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 493
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (1-492): 6.35e-136: 402: 39.80
+	Hs
		476418 UBC_HUMAN (1-685): 0: 846: 100.00		TRI39_HUMAN (6-492): 6.9e-127: 381: 27.48
+	Hs
		475297 UBC_HUMAN (1-685): 0: 846: 100.00		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Hs
		476635 UBC_HUMAN (1-685): 0: 846: 100.00		TRI17_HUMAN (2-492): 1.67e-104: 322: 26.80
+	Hs
		475680 UBC_HUMAN (1-685): 0: 846: 100.00		TRI26_HUMAN (1-490): 4.61e-103: 320: 25.73
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (8-487): 1.9e-103: 323: 23.94
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (5-491): 1.9e-126: 378: 35.22
+	Hs
		475177 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRIM5_HUMAN (1-493): 3.88e-147: 432: 100.00
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (5-491): 1.9e-126: 378: 35.22
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (5-491): 1.9e-126: 378: 35.22
+	Hs
		475134 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRI11_HUMAN (2-491): 2.14e-121: 365: 31.91
+	Hs
		924151 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI31_HUMAN (1-269): 5.66e-40: 150: 31.25