HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: HXD8 (P13378)
Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4)
Gene: HOXD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	8890171
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 290
+	Hs
		481109 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		HXD10_HUMAN (59-260): 6.68e-33: 125: 28.29
+	Hs
		481050 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		HXC6_HUMAN (66-273): 2.09e-29: 113: 28.24
+	Hs
		186628 HMGB3_HUMAN (13-181): 1.46e-41: 141: 71.60		MEOX1_HUMAN (27-280): 5.01e-32: 120: 22.05
+	Dm
		713732 Q9VUD3_DROME (2-95): 9.51e-28: 111: 21.28		ABDA_DROME (91-281): 1.8e-40: 149: 34.56
+	Hs
		186654 HMGB3_HUMAN (13-181): 1.46e-41: 141: 71.60		Q6FHY5_HUMAN (10-281): 4.37e-30: 116: 19.85
+	Dm
		121510 M9PFG6_DROME (7-95): 1.32e-25: 104: 21.35		ABDA_DROME (91-281): 1.8e-40: 149: 34.56
+	Dm
		120232 M9PCZ7_DROME (3-84): 1.09e-24: 103: 23.17		ABDA_DROME (91-281): 1.8e-40: 149: 34.56
+	Dm
		1014407 Q9VUD3_DROME (2-95): 9.51e-28: 111: 21.28		UBX_DROME (43-257): 2.96e-37: 137: 31.82
+	Dm
		121513 M9PFG6_DROME (7-95): 1.32e-25: 104: 21.35		UBX_DROME (43-257): 2.96e-37: 137: 31.82
+	Dm
		120234 M9PCZ7_DROME (3-84): 1.09e-24: 103: 23.17		UBX_DROME (43-257): 2.96e-37: 137: 31.82
+	Dm
		713651 SOX15_DROME (7-89): 3.22e-20: 90.1: 14.46		ABDA_DROME (91-281): 1.8e-40: 149: 34.56
+	Mm
		478349 Q60I23_MOUSE (3-94): 1.01e-24: 100: 23.91		HXA5_MOUSE (1-269): 2.05e-36: 132: 24.82
+	Hs
		634834 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		HXA5_HUMAN (1-269): 2.58e-36: 132: 24.82
+	Hs
		481117 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		HXA10_HUMAN (194-260): 3.76e-15: 77: 62.69
+	Hs
		634885 SOX17_HUMAN (7-90): 3.94e-22: 94.8: 19.05		HXA5_HUMAN (1-269): 2.58e-36: 132: 24.82
+	Hs
		872735 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		ALX4_HUMAN (7-281): 6.23e-33: 126: 18.55
+	Hs
		604795 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		HXB9_HUMAN (1-262): 8.34e-29: 112: 27.48
+	Hs
		942472 HM20B_HUMAN (64-165): 1.23e-15: 76: 32.35		GSC_HUMAN (75-287): 2.8e-30: 116: 19.74
+	Mm
		204335 SOX15_MOUSE (7-95): 2.7e-14: 70.9: 23.60		ALX4_MOUSE (15-282): 1.74e-28: 114: 18.55
+	Mm
		1049110 SOX8_MOUSE (7-86): 7.9e-22: 94.4: 18.75		HXC4_MOUSE (173-256): 1.03e-16: 79.7: 52.13