HitPredict

Interactor 1: IF4A (P10081)
ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
Gene: TIF1

Interactor 2: SSB1 (P11484)
Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)
Gene: SSB1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	27001512, 19536198, 16429126
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016887 - ATP hydrolysis activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 395 Sc			1 613
+	Sc
		485743 IF4A_YEAST (1-395): 9.95e-152: 435: 100.00		SSB2_YEAST (1-613): 0: 1118: 99.35
+	Sc
		513119 FAL1_YEAST (19-393): 1.59e-147: 425: 56.73		SSB1_YEAST (1-613): 0: 1128: 100.00
+	Sc
		769748 FAL1_YEAST (19-393): 1.59e-147: 425: 56.73		SSB2_YEAST (1-613): 0: 1118: 99.35
+	Sc
		510336 DBP2_YEAST (1-392): 1.76e-131: 390: 31.42		SSB1_YEAST (1-613): 0: 1128: 100.00
+	Sc
		624104 DBP2_YEAST (1-392): 1.76e-131: 390: 31.42		SSB2_YEAST (1-613): 0: 1118: 99.35
+	Sc
		415872 DED1_YEAST (3-395): 1.27e-125: 376: 30.19		SSB1_YEAST (1-613): 0: 1128: 100.00
+	Sc
		624216 DBP1_YEAST (3-393): 3.17e-128: 383: 29.93		SSB2_YEAST (1-613): 0: 1118: 99.35
+	Sc
		415991 DED1_YEAST (3-395): 1.27e-125: 376: 30.19		SSB2_YEAST (1-613): 0: 1118: 99.35
+	Sc
		511355 DHH1_YEAST (24-390): 2.1e-96: 298: 43.48		SSB1_YEAST (1-613): 0: 1128: 100.00
+	Sc
		761953 DHH1_YEAST (24-390): 2.1e-96: 298: 43.48		SSB2_YEAST (1-613): 0: 1118: 99.35
+	Hs
		503787 IF4A1_HUMAN (9-394): 1.03e-170: 484: 66.24		HSP7C_HUMAN (5-612): 0: 900: 59.84
+	Hs
		504069 IF4A2_HUMAN (8-394): 2.32e-170: 483: 65.04		HSP7C_HUMAN (5-612): 0: 900: 59.84
+	Hs
		504506 DDX17_HUMAN (1-395): 1.81e-132: 398: 31.85		HSP7C_HUMAN (5-612): 0: 900: 59.84
+	Hs
		503397 DDX5_HUMAN (1-394): 2.34e-132: 394: 31.27		HSP7C_HUMAN (5-612): 0: 900: 59.84
+	Hs
		133856 DDX3X_HUMAN (3-393): 2.68e-129: 388: 29.95		HSP7C_HUMAN (5-612): 0: 900: 59.84
+	Hs
		503580 IF4A3_HUMAN (3-394): 5.76e-126: 371: 61.58		HSP7C_HUMAN (5-612): 0: 900: 59.84