HitPredict

Interactor 1: RU2A (P09661)
U2 small nuclear ribonucleoprotein A' (U2 snRNP A')
Gene: SNRPA1

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_9~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071005 - U2-type precatalytic spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 95
+	Hs
		1293329 DAA11_HUMAN (1-247): 3.01e-45: 159: 21.34		LSM2_HUMAN (1-95): 4.23e-38: 124: 100.00
+	Hs
		485602 RU2A_HUMAN (1-255): 1.26e-53: 175: 100.00		SMD1_HUMAN (1-95): 6.69e-29: 101: 28.42
+	Hs
		485604 RU2A_HUMAN (1-255): 1.26e-53: 175: 100.00		SMD3_HUMAN (2-88): 6.47e-24: 89.6: 20.69
+	Hs
		485600 RU2A_HUMAN (1-255): 1.26e-53: 175: 100.00		RUXF_HUMAN (3-71): 2.46e-23: 86.9: 31.43
+	Dm
		1465921 RU2A_DROME (1-239): 9.16e-40: 139: 51.82		Q9VKW8_DROME (1-89): 2.59e-32: 111: 34.07
+	Sp
		206006 RU2A_SCHPO (2-230): 4.36e-38: 134: 41.60		SMD1_SCHPO (1-95): 3.64e-28: 100: 31.58
+	Dm
		232179 RU2A_DROME (1-239): 9.16e-40: 139: 51.82		SMD3_DROME (2-74): 2.75e-23: 88.4: 23.29
+	Dm
		1173245 RU2A_DROME (1-239): 9.16e-40: 139: 51.82		RUXF_DROME (3-84): 2.11e-23: 86.9: 26.83
+	Sp
		1462903 RU2A_SCHPO (2-230): 4.36e-38: 134: 41.60		SMD3_SCHPO (2-74): 1.26e-24: 90.4: 27.40
+	Dm
		1466495 AN32A_DROME (6-154): 2.85e-29: 112: 26.17		Q9VKW8_DROME (1-89): 2.59e-32: 111: 34.07
+	Dm
		1466516 AN32A_DROME (6-154): 2.85e-29: 112: 26.17		SMD1_DROME (1-94): 3.75e-29: 102: 30.85
+	Sc
		818067 RU2A_YEAST (14-227): 3.74e-32: 119: 24.07		LSM4_YEAST (1-83): 6.76e-22: 85.7: 22.83
+	Sc
		847841 RU2A_YEAST (14-227): 3.74e-32: 119: 24.07		SMD3_YEAST (2-91): 3.44e-22: 84.2: 18.89