HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	17494760, 31819114
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 1038
+	Hs
		337320 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		487203 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		433225 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (1-400): 1.3e-128: 403: 29.93
+	Hs
		487088 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		411564 ANDR_HUMAN (1-920): 0: 966: 100.00		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		433537 ANDR_HUMAN (1-920): 0: 966: 100.00		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79
+	Hs
		442764 ANDR_HUMAN (1-920): 0: 966: 100.00		HCK_HUMAN (76-388): 8.7e-112: 358: 34.40
+	Hs
		337828 ANDR_HUMAN (1-920): 0: 966: 100.00		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		487415 ANDR_HUMAN (1-920): 0: 966: 100.00		PTK6_HUMAN (124-385): 1.48e-49: 184: 40.91
+	Hs
		369651 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		368834 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		YES_HUMAN (1-400): 1.3e-128: 403: 29.93
+	Hs
		368894 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Rn
		411266 ESR1_RAT (378-904): 2.19e-130: 406: 20.94		SRC_RAT (1-400): 8.14e-126: 395: 31.17
+	Mm
		403414 ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30		SRC_MOUSE (1-400): 4.79e-125: 393: 31.17
+	Hs
		377057 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		377007 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		522762 RXRA_HUMAN (392-902): 7.05e-120: 374: 19.84		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		377006 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		337736 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		337741 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58