Protein: NCOA2
Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)

Gene: NCOA2
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q15596

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001162 - RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

396180

ESR1
Estrogen receptor

19

20

Small-scale

0.987

High

520078

ANDR
Androgen receptor

11

20

Small-scale

0.970

High

404077

GCR
Glucocorticoid receptor

9

20

Small-scale

0.964

High

520585

RARA
Retinoic acid receptor alpha

6

20

Small-scale

0.942

High

625819

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.922

High

1150400

ESR2
Estrogen receptor beta

5

20

Small-scale

0.914

High

543511

VDR
Vitamin D3 receptor

5

20

Small-scale

0.911

High

789501

PPARG
Peroxisome proliferator-activated receptor gamma

6

20

Small-scale

0.906

High

1150401

CBP
CREB-binding protein

4

20

Small-scale

0.891

High

1150386

NCOA1
Nuclear receptor coactivator 1

4

19

Small-scale

0.867

High

1134804

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

20

High-throughput

0.861

High

533346

THB
Thyroid hormone receptor beta

3

20

Small-scale

0.840

High

1067366

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.835

High

693323

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

20

Small-scale

0.800

High

1041753

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.778

High

1060605

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.778

High

533287

THA
Thyroid hormone receptor alpha

2

20

Small-scale

0.768

High

777285

AHR
Aryl hydrocarbon receptor

2

20

Small-scale

0.768

High

442941

PRGR
Progesterone receptor

2

20

Small-scale

0.754

High

1150420

NCOA3
Nuclear receptor coactivator 3

2

19

Small-scale

0.754

High

848780

MAGAA
Melanoma-associated antigen 10

5

12

High-throughput

0.716

High

137539

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.692

High

343259

ERR2
Steroid hormone receptor ERR2

1

20

Small-scale

0.647

High

543576

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.647

High

838236

STAT6
Signal transducer and activator of transcription 6

1

8

Small-scale

0.647

High

1150389

H31T
Histone H3.1t

1

7

Small-scale

0.647

High

799146

BRCA1
Breast cancer type 1 susceptibility protein

3

12

Small-scale

0.639

High

848870

MAGAB
Melanoma-associated antigen 11

2

12

Small-scale

0.631

High

413898

P53
Cellular tumor antigen p53

2

8

High-throughput

0.624

High

282941

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.621

High

522821

COT1
COUP transcription factor 1

1

20

Small-scale

0.621

High

833949

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.621

High

652519

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

Small-scale

0.618

High

1098886

SLAP1
Src-like-adapter

2

7

High-throughput

0.612

High

1150395

CARM1
Histone-arginine methyltransferase CARM1

2

8

Small-scale

0.602

High

714145

PML
Protein PML

2

11

Small-scale

0.595

High

872359

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

1087755

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1150416

KLF15
Krueppel-like factor 15

2

12

High-throughput

0.584

High

700521

PSB9
Proteasome subunit beta type-9

1

5

Small-scale

0.573

High

370678

FOS
Protein c-Fos

1

13

Small-scale

0.561

High

1150387

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.561

High

570893

MIF
Macrophage migration inhibitory factor

1

2

High-throughput

0.536

High

1099683

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

1150409

EGLN3
Prolyl hydroxylase EGLN3

1

14

High-throughput

0.536

High

1150413

FOXJ2
Forkhead box protein J2

1

14

High-throughput

0.536

High

943844

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.518

High

549162

CDK4
Cyclin-dependent kinase 4

1

6

Small-scale

0.501

High

718892

CCND3
G1/S-specific cyclin-D3

1

5

Small-scale

0.501

High

896487

ETV1
ETS translocation variant 1

1

20

Small-scale

0.501

High

979713

H4
Histone H4

1

7

Small-scale

0.501

High

1055021

MEF2C
Myocyte-specific enhancer factor 2C

1

5

Small-scale

0.501

High

1093233

FLII
Protein flightless-1 homolog

1

1

Small-scale

0.501

High

1150393

ANR11
Ankyrin repeat domain-containing protein 11

1

7

Small-scale

0.501

High

1150405

ANM1
Protein arginine N-methyltransferase 1

1

8

Small-scale

0.501

High

347044

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.489

High

276387

LIPA4
Liprin-alpha-4

1

7

Small-scale

0.481

High

851770

NKX21
Homeobox protein Nkx-2.1

1

20

Small-scale

0.481

High

1150410

TRXR2
Thioredoxin reductase 2, mitochondrial

1

1

Small-scale

0.481

High

1150419

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.480

High

143009

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

181516

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

210002

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.479

High

225004

TLX3
T-cell leukemia homeobox protein 3

1

19

High-throughput

0.479

High

239957

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

251589

CCNT1
Cyclin-T1

1

2

Small-scale

0.479

High

255804

USO1
General vesicular transport factor p115

1

10

Small-scale

0.479

High

291930

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

9

Small-scale

0.479

High

325851

UBR5
E3 ubiquitin-protein ligase UBR5

1

9

Small-scale

0.479

High

339756

KLF8
Krueppel-like factor 8

1

14

High-throughput

0.479

High

341574

EYA4
Protein phosphatase EYA4

1

7

High-throughput

0.479

High

378492

IL1A
Interleukin-1 alpha

1

3

Small-scale

0.479

High

474007

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

538398

EGR2
E3 SUMO-protein ligase EGR2

1

4

High-throughput

0.479

High

540875

ERG
Transcriptional regulator ERG

1

19

High-throughput

0.479

High

588782

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

697542

PYR1
Multifunctional protein CAD

1

1

Small-scale

0.479

High

725257

TLX1
T-cell leukemia homeobox protein 1

1

17

High-throughput

0.479

High

764777

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

775845

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

776197

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

846910

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

886887

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.479

High

930897

HSP72
Heat shock-related 70 kDa protein 2

1

8

Small-scale

0.479

High

938450

PAX9
Paired box protein Pax-9

1

15

High-throughput

0.479

High

942101

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

1047978

TLE3
Transducin-like enhancer protein 3

1

16

High-throughput

0.479

High

1056609

PAX8
Paired box protein Pax-8

1

15

High-throughput

0.479

High

1083366

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

7

High-throughput

0.479

High

1095534

LIPA1
Liprin-alpha-1

1

8

Small-scale

0.479

High

1109451

ATR
Serine/threonine-protein kinase ATR

1

6

Small-scale

0.479

High

1118710

KLF5
Krueppel-like factor 5

1

14

High-throughput

0.479

High

1130566

NCOA6
Nuclear receptor coactivator 6

1

13

Small-scale

0.479

High

1133423

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1150388

TBR1
T-box brain protein 1

1

7

High-throughput

0.479

High

1150390

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

1

Small-scale

0.479

High

1150391

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

7

Small-scale

0.479

High

1150392

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

14

Small-scale

0.479

High

1150394

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1150396

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.479

High

1150398

SP7
Transcription factor Sp7

1

14

High-throughput

0.479

High

1150399

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1150402

LHX4
LIM/homeobox protein Lhx4

1

5

High-throughput

0.479

High

1150404

FEV
Protein FEV

1

19

High-throughput

0.479

High

1150406

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1150407

WWTR1
WW domain-containing transcription regulator protein 1

1

7

High-throughput

0.479

High

1150408

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1150412

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1150415

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.479

High

1150418

MED23
Mediator of RNA polymerase II transcription subunit 23

1

2

High-throughput

0.479

High

1150403

TECT2
Tectonic-2

1

0

High-throughput

0.458

High

1150417

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1150421

PIAS3
E3 SUMO-protein ligase PIAS3

1

7

Small-scale

0.445

High

660633

IF4B
Eukaryotic translation initiation factor 4B

1

1

High-throughput

0.437

High

1063271

GOGA2
Golgin subfamily A member 2

1

10

High-throughput

0.437

High

1150411

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

14

High-throughput

0.437

High

231578

PRKY
Putative serine/threonine-protein kinase PRKY

1

3

High-throughput

0.407

High

852309

MMP13
Collagenase 3

1

0

Small-scale

0.249

Low

1059315

NKG2E
NKG2-E type II integral membrane protein

1

0

Small-scale

0.249

Low

1150397

ATLA2
Atlastin-2

1

0

High-throughput

0.249

Low

1150414

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025