Interactor 1: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF
Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25852190, 29777862, 32707033, 20936779, 35271311, 17979178, 19608861, 36931259 |
| Identification Methods | affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, pull down, two hybrid pooling approach, cross-linking study |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | 14-3-3~C1_1, 14-3-3~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0000165 - MAPK cascade GO:0005829 - cytosol |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
