Protein: SPTC1
Serine palmitoyltransferase 1 (SPT 1) (SPT1) (EC 2.3.1.50) (Long chain base biosynthesis protein 1)

Gene: SPTC1, LCB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 32
UniProt ID: P25045

Gene Ontology (top 5):
GO:0004758 - serine C-palmitoyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0017059 - serine palmitoyltransferase complex
GO:0030148 - sphingolipid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

668456

LCB2
Serine palmitoyltransferase 2

11

10

Small-scale

0.977

High

668465

ORM2
Protein ORM2

9

8

Small-scale

0.973

High

668458

ORM1
Protein ORM1

7

8

Small-scale

0.961

High

668445

SPTC1
Serine palmitoyltransferase 1

2

10

Small-scale

0.754

High

668467

TSC3
Serine palmitoyltransferase-regulating protein TSC3

8

1

Small-scale

0.746

High

668449

SAC1
Phosphatidylinositol-3-phosphatase SAC1

8

1

Small-scale

0.746

High

668457

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.518

High

486047

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.489

High

668455

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.479

High

668461

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

668463

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

382836

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.437

High

452824

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

578898

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.437

High

636791

PUR6
Phosphoribosylaminoimidazole carboxylase

1

3

High-throughput

0.437

High

668446

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

668447

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

668448

BMH1
Protein BMH1

1

2

High-throughput

0.437

High

668451

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.437

High

668454

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

668459

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

668460

HST2
NAD-dependent protein deacetylase HST2

1

2

High-throughput

0.437

High

668464

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.437

High

525987

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.407

High

543906

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.407

High

668450

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.407

High

571803

SNA3
Protein SNA3

1

0

High-throughput

0.282

High

668452

MID2
Cell wall integrity sensor MID2

1

0

High-throughput

0.282

High

668466

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.238

Low

668453

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low

668462

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025