Protein: SPTC1
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)

Gene: SPTC1, SPTLC1
Organism: Homo sapiens
Interactions: 185
UniProt ID: O15269

Gene Ontology (top 5):
GO:0004758 - serine C-palmitoyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006665 - sphingolipid metabolic process
GO:0006686 - sphingomyelin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184772

SPTC2
Serine palmitoyltransferase 2

3

11

Small-scale

0.843

High

184872

ORML3
ORM1-like protein 3

2

8

Small-scale

0.776

High

184850

ORML2
ORM1-like protein 2

1

8

High-throughput

0.691

High

184932

ORML1
ORM1-like protein 1

1

8

High-throughput

0.691

High

184926

SPTC3
Serine palmitoyltransferase 3

1

11

Small-scale

0.680

High

184787

EGFR
Epidermal growth factor receptor

3

3

High-throughput

0.640

High

184799

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.611

High

184912

UN93B
Protein unc-93 homolog B1

2

1

High-throughput

0.601

High

184783

ABCA1
Phospholipid-transporting ATPase ABCA1

2

1

Small-scale

0.594

High

184880

SPTSB
Serine palmitoyltransferase small subunit B

1

5

Small-scale

0.590

High

184891

SPTSA
Serine palmitoyltransferase small subunit A

1

5

Small-scale

0.590

High

184775

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

184853

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.552

High

129919

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

181206

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.536

High

184782

SC31A
Protein transport protein Sec31A

1

1

High-throughput

0.536

High

184794

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.536

High

184805

CALX
Calnexin

1

1

High-throughput

0.536

High

184808

CNR2
Cannabinoid receptor 2

1

4

Small-scale

0.536

High

184811

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

184813

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

184822

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.536

High

184826

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

184941

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

High-throughput

0.515

High

184793

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

184798

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

184818

COPD
Coatomer subunit delta

1

0

High-throughput

0.513

High

184825

COPB
Coatomer subunit beta

1

0

High-throughput

0.513

High

184885

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

184887

NICA
Nicastrin

1

0

High-throughput

0.513

High

184898

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

184916

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

184931

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

184934

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.513

High

184905

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.493

High

184789

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.489

High

184824

JAK3
Tyrosine-protein kinase JAK3

1

3

High-throughput

0.489

High

184844

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

184847

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.489

High

184863

MON2
Protein MON2 homolog

1

1

High-throughput

0.489

High

184888

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.489

High

184921

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

1

High-throughput

0.489

High

184929

CDK12
Cyclin-dependent kinase 12

1

2

High-throughput

0.489

High

173777

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

184796

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

184797

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.479

High

184812

BASI
Basigin

1

1

High-throughput

0.479

High

184830

RAC3
Ras-related C3 botulinum toxin substrate 3

1

6

High-throughput

0.479

High

184831

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

184833

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

184835

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

184838

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

184857

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

184858

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

184875

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

184876

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

184904

DERL1
Derlin-1

1

1

High-throughput

0.479

High

184913

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

184923

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.470

High

184947

MAGD1
Melanoma-associated antigen D1

1

1

High-throughput

0.470

High

184785

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.458

High

184820

EMD
Emerin

1

0

High-throughput

0.458

High

184829

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

184852

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

184902

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

184908

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

High-throughput

0.458

High

184918

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

184946

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.458

High

184948

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

Small-scale

0.458

High

184791

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.457

High

184792

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.457

High

184878

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

184883

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.445

High

184942

S27A5
Long-chain fatty acid transport protein 5

1

3

High-throughput

0.445

High

184773

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

184777

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

184781

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.437

High

184786

BRD1
Bromodomain-containing protein 1

1

2

High-throughput

0.437

High

184800

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

184804

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

184810

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

184814

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

184816

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.437

High

184823

RND2
Rho-related GTP-binding protein RhoN

1

6

High-throughput

0.437

High

184827

MOT1
Monocarboxylate transporter 1

1

2

High-throughput

0.437

High

184828

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

184834

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.437

High

184837

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

184839

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

184842

CUL3
Cullin-3

1

2

High-throughput

0.437

High

184849

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

184855

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

184860

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

184862

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.437

High

184865

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

184867

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

184870

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.437

High

184877

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.437

High

184890

HDA10
Polyamine deacetylase HDAC10

1

2

High-throughput

0.437

High

184892

MFRN2
Mitoferrin-2

1

1

High-throughput

0.437

High

184894

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.437

High

184899

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

184901

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.437

High

184910

TOLIP
Toll-interacting protein

1

1

High-throughput

0.437

High

184914

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

184915

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

184917

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

184922

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

184925

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

184930

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.437

High

184936

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

184938

UBQL2
Ubiquilin-2

1

3

High-throughput

0.437

High

184943

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

184778

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

184933

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

97209

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

104067

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

184795

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

184803

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

184807

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.407

High

184817

S6A12
Sodium- and chloride-dependent betaine transporter

1

4

High-throughput

0.407

High

184873

S35F6
Solute carrier family 35 member F6

1

2

High-throughput

0.407

High

184927

ATD3A
ATPase family AAA domain-containing protein 3A

1

4

High-throughput

0.407

High

184939

LAT2
Large neutral amino acids transporter small subunit 2

1

2

High-throughput

0.407

High

184949

X6RFA8
Solute carrier family 25 member 28

1

1

High-throughput

0.407

High

184802

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

184821

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.279

Low

184832

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.279

Low

184836

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.279

Low

184843

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.279

Low

184856

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

184882

FA76A
Protein FAM76A

1

0

High-throughput

0.279

Low

184895

ATG4C
Cysteine protease ATG4C

1

0

High-throughput

0.279

Low

184896

TCAL4
Transcription elongation factor A protein-like 4

1

0

High-throughput

0.279

Low

184897

NRBF2
Nuclear receptor-binding factor 2

1

0

High-throughput

0.279

Low

184903

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.279

Low

184911

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.279

Low

184920

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.279

Low

184935

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

184937

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

184945

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

184780

RGS20
Regulator of G-protein signaling 20

1

0

High-throughput

0.269

Low

184859

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.268

Low

184864

ANR23
Ankyrin repeat domain-containing protein 23

1

0

High-throughput

0.268

Low

184871

SLN12
Ribonuclease SLFN12

1

0

High-throughput

0.268

Low

184886

SOCS4
Suppressor of cytokine signaling 4

1

0

High-throughput

0.268

Low

184940

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

Small-scale

0.251

Low

184774

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

184779

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.249

Low

184788

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

184790

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

184801

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

184806

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.249

Low

184809

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

184815

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.249

Low

184819

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

184840

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

184841

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

184845

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.249

Low

184846

FSCN1
Fascin

1

0

High-throughput

0.249

Low

184848

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.249

Low

184851

PKHG4
Puratrophin-1

1

0

High-throughput

0.249

Low

184861

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

184866

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

184869

CMIP
C-Maf-inducing protein

1

0

High-throughput

0.249

Low

184879

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

184881

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

184884

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

184889

FBX32
F-box only protein 32

1

0

Small-scale

0.249

Low

184893

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

184907

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low

184909

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

184919

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

184924

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

184928

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

184944

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.249

Low

844

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

87274

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

184776

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

184784

GTR10
Solute carrier family 2, facilitated glucose transporter member 10

1

0

High-throughput

0.232

Low

184854

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

184868

CTL2
Choline transporter-like protein 2

1

0

High-throughput

0.232

Low

184874

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

184900

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

184906

IFT27
Intraflagellar transport protein 27 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025