Interactor 1: Q6NR46 (Q6NR46)
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (Serine-palmitoyl-CoA transferase 1)
Gene: Spt-I

Interactor 2: Q9V3F2 (Q9V3F2)
serine C-palmitoyltransferase (EC 2.3.1.50)
Gene: lace

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 22036573, 38944040
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Aminotran_1_2~Aminotran_1_2
Common GO terms GO:0004758 - serine C-palmitoyltransferase activity
GO:0017059 - serine palmitoyltransferase complex
GO:0030170 - pyridoxal phosphate binding
GO:0046512 - sphingosine biosynthetic process
GO:0046513 - ceramide biosynthetic process
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 468
Dm

1 597
+ Hs
+ Hs
+ Mm
+ At
+ Mm
+ Hs
+ Sc
+ Ec
+ Sc
+ Sc

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Last updated: 11Aug2025