Protein: SPTC2
Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

Gene: SPTC2, SPTLC2
Organism: Homo sapiens
Interactions: 106
UniProt ID: O15270

Gene Ontology (top 5):
GO:0004758 - serine C-palmitoyltransferase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006686 - sphingomyelin biosynthetic process
GO:0017059 - serine palmitoyltransferase complex
GO:0030148 - sphingolipid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184772

SPTC1
Serine palmitoyltransferase 1

3

11

Small-scale

0.843

High

184980

EVA1C
Protein eva-1 homolog C

4

1

High-throughput

0.630

High

185034

UN93B
Protein unc-93 homolog B1

2

1

High-throughput

0.601

High

185021

SPTSB
Serine palmitoyltransferase small subunit B

1

5

Small-scale

0.590

High

185025

SPTSA
Serine palmitoyltransferase small subunit A

1

5

Small-scale

0.590

High

184952

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

185027

BSCL2
Seipin

2

0

High-throughput

0.576

High

185007

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

1

High-throughput

0.574

High

185024

LPAR1
Lysophosphatidic acid receptor 1

2

4

High-throughput

0.549

High

184959

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.536

High

184962

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

184976

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.536

High

184984

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

0

High-throughput

0.513

High

184986

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

185028

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

184981

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.489

High

184988

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

185010

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.489

High

185035

TSN10
Tetraspanin-10

1

1

High-throughput

0.489

High

185037

LPAR2
Lysophosphatidic acid receptor 2

1

4

High-throughput

0.489

High

185041

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

185050

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.489

High

185051

PCDGL
Protocadherin gamma-C4

1

1

High-throughput

0.489

High

185048

NOTC3
Neurogenic locus notch homolog protein 3

1

0

Small-scale

0.480

High

173778

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

184957

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.479

High

185001

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

185002

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

185033

DERL1
Derlin-1

1

1

High-throughput

0.479

High

184971

CCNF
Cyclin-F

1

1

High-throughput

0.470

High

184978

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

0

High-throughput

0.458

High

185032

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

184993

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.445

High

185023

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

185049

S27A5
Long-chain fatty acid transport protein 5

1

2

High-throughput

0.445

High

184951

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

184954

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

184956

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.437

High

184958

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

184960

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

184961

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

184963

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

184966

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

184969

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

184977

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

184979

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

184985

CUL3
Cullin-3

1

2

High-throughput

0.437

High

184990

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.437

High

184992

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

184997

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

185003

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

185006

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

185013

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.437

High

185018

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.437

High

185019

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.437

High

185029

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

185036

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

185039

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

185043

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.437

High

185045

UBQL2
Ubiquilin-2

1

3

High-throughput

0.437

High

185005

RIC3
Protein RIC-3

1

0

High-throughput

0.426

High

185008

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.426

High

47858

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

104068

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

184964

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

184965

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

184967

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

184968

SC6A4
Sodium-dependent serotonin transporter

1

4

High-throughput

0.407

High

184973

S6A12
Sodium- and chloride-dependent betaine transporter

1

4

High-throughput

0.407

High

184974

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

4

High-throughput

0.407

High

184975

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.407

High

184995

S35F1
Solute carrier family 35 member F1

1

2

High-throughput

0.407

High

185000

S39A4
Zinc transporter ZIP4

1

2

High-throughput

0.407

High

185014

S39AB
Zinc transporter ZIP11

1

2

High-throughput

0.407

High

185015

S35F6
Solute carrier family 35 member F6

1

2

High-throughput

0.407

High

185020

ZNT7
Zinc transporter 7

1

1

High-throughput

0.407

High

185030

S1PR3
Sphingosine 1-phosphate receptor 3

1

4

High-throughput

0.407

High

185038

S6A13
Sodium- and chloride-dependent GABA transporter 2

1

4

High-throughput

0.407

High

185040

ATD3A
ATPase family AAA domain-containing protein 3A

1

4

High-throughput

0.407

High

185046

LAT2
Large neutral amino acids transporter small subunit 2

1

2

High-throughput

0.407

High

184950

SPIT2
Kunitz-type protease inhibitor 2

3

0

High-throughput

0.347

High

184991

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

2

0

High-throughput

0.318

High

185017

F241A
Uncharacterized protein FAM241A

2

0

High-throughput

0.313

High

184955

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

184972

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.279

Low

184994

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

184996

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

185011

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.279

Low

185016

MYCT1
Myc target protein 1

1

0

High-throughput

0.279

Low

185022

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.279

Low

184983

ROM1
Rod outer segment membrane protein 1

1

0

High-throughput

0.269

Low

184970

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

184982

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

0

High-throughput

0.249

Low

184987

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

184989

EREP1
Endosomal transmembrane epsin interactor 1

1

0

High-throughput

0.249

Low

185012

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

185026

WBP1
WW domain-binding protein 1

1

0

High-throughput

0.249

Low

185031

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.249

Low

185042

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

185044

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

High-throughput

0.249

Low

185047

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low

184953

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

184998

S35E4
Solute carrier family 35 member E4

1

0

High-throughput

0.232

Low

184999

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

185004

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.232

Low

185009

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025