HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AT2B1 (P20020)
Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1)
Gene: ATP2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1220
+	Hs
		496323 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT2B4_HUMAN (7-1220): 0: 1207: 73.15
+	Mm
		498086 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8C048_MOUSE (1-1117): 0: 1154: 80.59
+	Mm
		100205 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		F7AAP4_MOUSE (7-1126): 0: 1117: 77.52
+	Dm
		1359876 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9V4C7_DROME (21-1142): 0: 1044: 62.47
+	Hs
		392995 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT1A1_HUMAN (41-1082): 0: 770: 22.46
+	Hs
		496196 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT1A3_HUMAN (35-1082): 0: 761: 22.15
+	Hs
		496237 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT2A2_HUMAN (50-1078): 0: 759: 25.44
+	Hs
		496589 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AT1A2_HUMAN (40-1082): 0: 758: 22.71
+	Mm
		223146 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AT2A2_MOUSE (50-1091): 0: 793: 25.29
+	Rn
		416147 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AT1A1_RAT (40-1082): 0: 770: 22.44
+	Rn
		94112 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AT1A1_RAT (40-1082): 0: 770: 22.44
+	Rn
		513722 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AT2A2_RAT (50-1091): 0: 762: 25.23
+	Rn
		94131 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AT2A2_RAT (50-1091): 0: 762: 25.23
+	Rn
		416169 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AT1A3_RAT (38-1082): 0: 759: 22.21
+	Rn
		94114 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AT1A3_RAT (38-1082): 0: 759: 22.21
+	Hs
		561576 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		AT2A2_HUMAN (50-1078): 0: 759: 25.44