HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	17512525
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 735
+	Hs
		496604 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A3_HUMAN (1-735): 0: 791: 79.14
+	Hs
		270366 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A5_HUMAN (46-730): 0: 706: 41.42
+	Hs
		1057021 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		KS6A6_HUMAN (28-734): 0: 761: 74.72
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (326-719): 8.47e-124: 379: 22.11
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92
+	Hs
		496317 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6B1_HUMAN (393-727): 4.37e-113: 353: 24.65
+	Hs
		496248 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71
+	Hs
		496307 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCB_HUMAN (406-704): 9.71e-114: 349: 30.03
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (408-695): 1.9e-108: 348: 28.48
+	Hs
		496305 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCG_HUMAN (416-712): 4.65e-113: 347: 27.97
+	Rn
		581976 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KAPCB_RAT (416-712): 7.52e-113: 346: 29.90
+	Rn
		94199 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KAPCB_RAT (416-712): 7.52e-113: 346: 29.90
+	Mm
		397198 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KAPCA_MOUSE (416-712): 3.33e-113: 347: 29.58
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92
+	Hs
		503261 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71
+	Hs
		503264 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCB_HUMAN (406-704): 9.71e-114: 349: 30.03
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (408-695): 1.9e-108: 348: 28.48
+	Hs
		503263 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCG_HUMAN (416-712): 4.65e-113: 347: 27.97
+	Hs
		116961 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SGK1_HUMAN (415-667): 1.07e-29: 124: 33.85
+	Bt
		337290 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		KAPCA_BOVIN (406-712): 3.48e-113: 347: 28.97