HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 772
+	Hs
		496894 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		152632 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		496775 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GBB1_HUMAN (567-770): 1.63e-38: 148: 17.62
+	Hs
		496503 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		LIS1_HUMAN (686-769): 6.84e-19: 91.8: 22.35
+	Hs
		496777 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GBB2_HUMAN (688-771): 3.6e-14: 76.4: 16.47
+	Hs
		196948 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRP4_HUMAN (555-763): 6.48e-12: 70.9: 28.24
+	Mm
		497983 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNB5_MOUSE (609-770): 9.68e-25: 109: 18.50
+	Hs
		653951 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12
+	Hs
		152663 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		WDR5B_HUMAN (284-559): 4.84e-33: 132: 8.80
+	Hs
		152622 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12
+	Mm
		903669 KMT2C_MOUSE (228-587): 6.06e-09: 61.9: 16.84		WDR5_MOUSE (284-560): 2.42e-32: 130: 9.12
+	Hs
		903374 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12
+	Hs
		1056932 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52
+	Hs
		921574 SPEG_HUMAN (183-564): 6e-23: 107: 16.71		GBB2_HUMAN (688-771): 3.6e-14: 76.4: 16.47