Protein: COX2
Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II)

Gene: COX2
Organism: Saccharomyces cerevisiae S288C
Interactions: 77
UniProt ID: P00410

Gene Ontology (top 5):
GO:0004129 - cytochrome-c oxidase activity
GO:0005507 - copper ion binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360302

COX1
Cytochrome c oxidase subunit 1

9

1

Small-scale

0.961

High

360626

COX4
Cytochrome c oxidase subunit 4, mitochondrial

7

0

Small-scale

0.902

High

360623

COX6
Cytochrome c oxidase subunit 6, mitochondrial

5

0

Small-scale

0.852

High

360620

COX3
Cytochrome c oxidase subunit 3

3

0

Small-scale

0.785

High

360691

COA6
Cytochrome c oxidase assembly factor 6

3

0

Small-scale

0.775

High

360633

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

7

3

Small-scale

0.740

High

360621

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

2

1

Small-scale

0.737

High

360641

ADT2
ADP,ATP carrier protein 2

4

1

Small-scale

0.691

High

360681

RCF1
Respiratory supercomplex factor 1, mitochondrial

5

0

Small-scale

0.672

High

360683

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

4

0

Small-scale

0.654

High

360646

MSS51
Protein MSS51, mitochondrial

4

0

Small-scale

0.648

High

360642

SCO1
Protein SCO1, mitochondrial

3

2

Small-scale

0.643

High

360675

COX18
Cytochrome c oxidase assembly protein COX18, mitochondrial

3

1

Small-scale

0.633

High

360650

MIC60
MICOS complex subunit MIC60

3

0

High-throughput

0.628

High

360658

COX14
Cytochrome c oxidase assembly protein COX14

3

0

Small-scale

0.628

High

360660

OXA1
Mitochondrial inner membrane protein OXA1

2

1

Small-scale

0.624

High

360622

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

1

High-throughput

0.618

High

357870

CYB
Cytochrome b

3

0

Small-scale

0.613

High

360627

COX8
Cytochrome c oxidase subunit 8, mitochondrial

3

0

Small-scale

0.597

High

360680

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

0

High-throughput

0.586

High

360634

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

2

3

Small-scale

0.584

High

360665

PHB1
Prohibitin-1

2

4

Small-scale

0.584

High

360676

SHY1
Cytochrome oxidase assembly protein SHY1

2

1

Small-scale

0.584

High

360639

COX7
Cytochrome c oxidase subunit 7, mitochondrial

2

0

Small-scale

0.560

High

360631

CY1
Cytochrome c1, heme protein, mitochondrial

2

0

Small-scale

0.559

High

360649

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

2

0

Small-scale

0.559

High

360677

RCF2
Respiratory supercomplex factor 2, mitochondrial

2

0

Small-scale

0.559

High

64203

YP010
UPF0495 protein YPR010C-A

1

0

Small-scale

0.517

High

360652

SCO2
Protein SCO2, mitochondrial

1

2

Small-scale

0.515

High

360662

MMF1
Protein MMF1, mitochondrial

1

1

High-throughput

0.515

High

360669

COX16
Cytochrome c oxidase assembly protein COX16, mitochondrial

1

0

Small-scale

0.513

High

360686

YD157
Uncharacterized protein YDL157C, mitochondrial

1

0

Small-scale

0.513

High

360671

BXI1
Bax inhibitor 1

1

0

Small-scale

0.493

High

360628

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.479

High

360638

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.479

High

360644

NFS1
Cysteine desulfurase, mitochondrial

1

1

Small-scale

0.479

High

360647

ACPM
Acyl carrier protein, mitochondrial

1

1

Small-scale

0.479

High

360653

ATPG
ATP synthase subunit gamma, mitochondrial

1

1

High-throughput

0.479

High

360659

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

2

High-throughput

0.479

High

360673

PHB2
Prohibitin-2

1

4

High-throughput

0.479

High

357739

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.458

High

357789

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

0

High-throughput

0.458

High

360624

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

360625

ATPB
ATP synthase subunit beta, mitochondrial

1

0

Small-scale

0.458

High

360629

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

360635

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.458

High

360636

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

1

0

High-throughput

0.458

High

360637

ATPO
ATP synthase subunit 5, mitochondrial

1

0

High-throughput

0.458

High

360640

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

360648

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.458

High

360651

QCR10
Cytochrome b-c1 complex subunit 10, mitochondrial

1

0

High-throughput

0.458

High

360654

MRX3
MIOREX complex component 3

1

0

High-throughput

0.458

High

360655

MBA1
Inner membrane mitoribosome receptor MBA1, mitochondrial

1

0

High-throughput

0.458

High

360656

MIC12
MICOS complex subunit MIC12

1

0

High-throughput

0.458

High

360657

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

360661

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

360663

COA1
Cytochrome c oxidase assembly factor 1

1

0

Small-scale

0.458

High

360664

INA22
Inner membrane assembly complex subunit 22

1

0

High-throughput

0.458

High

360666

MSS2
Protein MSS2, mitochondrial

1

0

Small-scale

0.458

High

360667

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

Small-scale

0.458

High

360672

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

360674

TIM21
Mitochondrial import inner membrane translocase subunit TIM21

1

0

Small-scale

0.458

High

360678

ATP23
Mitochondrial inner membrane protease ATP23

1

0

High-throughput

0.458

High

360679

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

360682

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

360684

ATG33
Autophagy-related protein 33

1

0

High-throughput

0.458

High

360685

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

Small-scale

0.458

High

360687

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.458

High

360690

COA3
Cytochrome c oxidase assembly factor 3, mitochondrial

1

0

Small-scale

0.458

High

360643

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

360632

COX9
Cytochrome c oxidase subunit 9, mitochondrial

1

0

Small-scale

0.426

High

360688

COX26
Cytochrome c oxidase subunit 26, mitochondrial

1

0

Small-scale

0.426

High

360670

DPH4
Diphthamide biosynthesis protein 4

1

1

High-throughput

0.407

High

360630

CDC31
Cell division control protein 31

1

0

Small-scale

0.249

Low

360645

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

360668

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

360689

YB255
Uncharacterized protein YBR255C-A

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025