HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

The method score is based on:

Property	Details
Experiments	26075355, 29976090, 30120248, 29507222, 29669822, 31375263
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, unspecified method
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0019899 - enzyme binding and 4 others more... GO:0031625 - ubiquitin protein ligase binding GO:0043231 - intracellular membrane-bounded organelle GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	654
Hs

1	440

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024