HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UBE3B (Q7Z3V4)
Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)
Gene: UBE3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 1068
+	Hs
		508015 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		UBE3C_HUMAN (6-1068): 0: 579: 25.55
+	Hs
		507111 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		NEDD4_HUMAN (604-1066): 1.86e-158: 505: 28.54
+	Hs
		507318 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		ITCH_HUMAN (604-1066): 1.36e-161: 502: 28.02
+	Hs
		507665 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		NEDD4_HUMAN (604-1066): 1.86e-158: 505: 28.54
+	Hs
		508443 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		ITCH_HUMAN (604-1066): 1.36e-161: 502: 28.02
+	Hs
		131689 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		WWP2_HUMAN (655-1066): 6.27e-159: 494: 29.30
+	Hs
		508467 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		NED4L_HUMAN (604-1066): 8.59e-159: 497: 27.68
+	Hs
		131690 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		WWP2_HUMAN (655-1066): 6.27e-159: 494: 29.30
+	Hs
		508598 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		WWP1_HUMAN (615-1066): 2.41e-153: 481: 26.71
+	Sp
		151804 UBI4P_SCHPO (1-228): 1.77e-91: 275: 96.05		PTR1_SCHPO (467-1068): 1.68e-145: 485: 24.49
+	Hs
		507253 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		HUWE1_HUMAN (608-1068): 7.3e-141: 471: 30.02
+	Hs
		507377 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		SMUF2_HUMAN (646-1065): 1.31e-150: 468: 27.25
+	Hs
		508210 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		HUWE1_HUMAN (608-1068): 7.3e-141: 471: 30.02
+	Hs
		508666 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		SMUF1_HUMAN (641-1065): 1.04e-150: 469: 27.64
+	Hs
		508655 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		SMUF2_HUMAN (646-1065): 1.31e-150: 468: 27.25
+	Sc
		509564 UBI4P_YEAST (1-228): 3.4e-91: 274: 96.05		RSP5_YEAST (604-1066): 8.15e-154: 479: 27.31
+	Dm
		1489825 Q9W418_DROME (1-228): 1.41e-93: 285: 100.00		Q9W325_DROME (645-1067): 1.46e-140: 431: 29.81
+	At
		1167700 UBQ3_ARATH (1-228): 1.09e-94: 281: 96.05		UPL1_ARATH (645-1059): 5.47e-51: 199: 32.08
+	At
		1167704 UBQ3_ARATH (1-228): 1.09e-94: 281: 96.05		UPL2_ARATH (645-1065): 2.02e-50: 197: 31.79
+	Hs
		508187 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		HECW1_HUMAN (678-1067): 4.14e-46: 183: 33.08