HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	25760602, 35384245
Identification Methods	x-ray crystallography, pull down, proximity labelling technology
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 435
+	Hs
		507980 FGFR1_HUMAN (1-822): 0: 861: 100.00		PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74
+	Hs
		601500 FGFR2_HUMAN (1-821): 0: 803: 71.21		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		573629 EPHA5_HUMAN (3-791): 0: 639: 19.15		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		573583 EPHA8_HUMAN (3-819): 0: 603: 19.35		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		607948 FGFR4_HUMAN (29-808): 0: 664: 55.60		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		507959 FGFR1_HUMAN (1-822): 0: 861: 100.00		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		573718 NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		601501 FGFR2_HUMAN (1-821): 0: 803: 71.21		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		616944 EPHA8_HUMAN (3-819): 0: 603: 19.35		PTPRD_HUMAN (1-278): 8.51e-109: 354: 31.45
+	Hs
		609260 FGFR3_HUMAN (6-821): 0: 730: 61.22		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		601466 FGFR2_HUMAN (1-821): 0: 803: 71.21		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Hs
		607949 FGFR4_HUMAN (29-808): 0: 664: 55.60		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		872429 EPHA5_HUMAN (3-791): 0: 639: 19.15		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		985961 EPHA7_HUMAN (3-783): 0: 629: 19.40		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		872635 EPHA4_HUMAN (3-783): 0: 620: 19.44		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		665257 EPHA2_HUMAN (3-819): 0: 583: 18.68		PTPRO_HUMAN (20-274): 4.19e-48: 178: 38.31
+	Hs
		665220 EPHA2_HUMAN (3-819): 0: 583: 18.68		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		607888 FGFR4_HUMAN (29-808): 0: 664: 55.60		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Mm
		546284 NTRK2_MOUSE (111-762): 1.43e-163: 497: 23.74		PTN11_MOUSE (39-274): 4.54e-49: 177: 38.80
+	Rn
		783507 NTRK2_RAT (111-762): 4.27e-163: 496: 23.89		PTN11_RAT (39-274): 1.22e-48: 176: 38.80