HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.990

Property	Details
Experiments	20005846, 28190767, 34599178, 35170849, 38803224, 17006537, 23986494, 25494483, 26789245, 22791023, 28319114, 28978479, 30017913, 30901564, 29694895, 35851409, 36631489, 36720498, 37431163, 23727886 and 3 others more... 24469399, 24726327, 21455180
Identification Methods	pull down, affinity chromatography technology, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	E3_UbLigase_RBR~ubiquitin, IBR_1~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 1072
+	Hs
		508895 UBC_HUMAN (1-685): 0: 857: 100.00		ARI1_HUMAN (600-1058): 4.36e-118: 377: 13.84
+	Hs
		507311 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Mm
		509228 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		RNF31_MOUSE (1-1072): 0: 1084: 85.54
+	Hs
		334978 UBC_HUMAN (1-685): 0: 857: 100.00		ARI2_HUMAN (654-1044): 1.1e-91: 304: 15.59
+	Hs
		508755 UBC_HUMAN (1-685): 0: 857: 100.00		AKIB1_HUMAN (431-1040): 3.99e-81: 289: 12.12
+	Hs
		508200 UBC_HUMAN (1-685): 0: 857: 100.00		R144B_HUMAN (679-926): 1.06e-59: 209: 20.23
+	Hs
		507690 UBC_HUMAN (1-685): 0: 857: 100.00		R144A_HUMAN (695-926): 2.88e-58: 204: 20.33
+	Hs
		508163 UBC_HUMAN (1-685): 0: 857: 100.00		RN19B_HUMAN (698-946): 5.68e-42: 167: 22.43
+	Dm
		509801 UBIQP_DROME (1-610): 0: 759: 99.84		LUBEL_DROME (180-625): 1.04e-69: 258: 17.33
+	Hs
		508777 UBC_HUMAN (1-685): 0: 857: 100.00		ZRAN1_HUMAN (226-379): 6.28e-20: 97.7: 19.44
+	Dm
		1304608 Q9W418_DROME (229-685): 0: 567: 99.78		LUBEL_DROME (180-625): 1.04e-69: 258: 17.33
+	Sc
		509496 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		HEL1_YEAST (621-1042): 2.14e-88: 296: 15.23
+	Dr
		49052 F1QHN6_DANRE (229-685): 0: 566: 99.78		ZRN1B_DANRE (159-353): 2.68e-13: 76.2: 15.42
+	Hs
		334977 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		ARI2_HUMAN (654-1044): 1.1e-91: 304: 15.59
+	Hs
		507267 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		CUL9_HUMAN (622-1043): 6.83e-83: 298: 14.88
+	Mm
		508998 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		RN216_MOUSE (609-992): 9.6e-63: 231: 13.97
+	Hs
		507240 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		RN19B_HUMAN (698-946): 5.68e-42: 167: 22.43
+	Hs
		987258 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		ZRAN1_HUMAN (226-379): 6.28e-20: 97.7: 19.44
+	Mm
		509124 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		ZRAN1_MOUSE (159-354): 1.05e-12: 74.3: 14.63