HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	30021884, 37071682
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0046982 - protein heterodimerization activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 126
+	Hs
		420797 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1J_HUMAN (1-126): 7.3e-55: 169: 97.62
+	Hs
		509018 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		241433 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		508918 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		508891 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1D_HUMAN (1-126): 3.03e-54: 167: 98.41
+	Hs
		509103 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H2B1L_HUMAN (1-126): 2.43e-53: 165: 97.62
+	Hs
		973343 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		241507 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		918302 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Sc
		355737 TOP2_YEAST (24-1404): 0: 1262: 41.63		H2B2_YEAST (3-125): 4.15e-41: 134: 71.55
+	Sc
		355300 TOP2_YEAST (24-1404): 0: 1262: 41.63		H2B1_YEAST (4-125): 8.17e-37: 123: 72.13