HitPredict

Interactor 1: NT2NC (P0DPK4)
Notch homolog 2 N-terminal-like protein C
Gene: NOTCH2NLC

Interactor 2: NET4 (Q9HB63)
Netrin-4 (Beta-netrin) (Hepar-derived netrin-like protein)
Gene: NTN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	unassigned1304
Identification Methods	validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 293 Hs			1 628
+	Hs
		1277414 NT2NA_HUMAN (22-229): 1.44e-15: 76.2: 30.70		NET4_HUMAN (1-628): 3.13e-149: 446: 100.00
+	Hs
		340703 NOTC2_HUMAN (6-246): 3.47e-10: 62.8: 21.52		NET1_HUMAN (12-628): 1.01e-115: 359: 29.37
+	Hs
		1355973 JAG2_HUMAN (51-239): 1.67e-18: 87.4: 34.03		NET5_HUMAN (109-627): 3.95e-78: 258: 22.71
+	Hs
		857512 NOTC1_HUMAN (6-165): 1.75e-14: 75.8: 30.49		NET5_HUMAN (109-627): 3.95e-78: 258: 22.71
+	Hs
		1355971 NOTC3_HUMAN (51-255): 5.75e-11: 65.1: 29.08		NET5_HUMAN (109-627): 3.95e-78: 258: 22.71
+	Hs
		1047665 NOTC2_HUMAN (6-246): 3.47e-10: 62.8: 21.52		NET5_HUMAN (109-627): 3.95e-78: 258: 22.71
+	Dm
		663795 SLIT_DROME (11-123): 2.86e-12: 68.9: 23.58		NETB_DROME (14-231): 9.88e-45: 172: 21.52
+	Dm
		517393 CRB_DROME (61-198): 5.42e-10: 62: 33.56		NETB_DROME (14-231): 9.88e-45: 172: 21.52
+	Dm
		1175444 TENA_DROME (2-103): 8.06e-10: 61.6: 14.73		NETB_DROME (14-231): 9.88e-45: 172: 21.52
+	Dm
		262791 TENM_DROME (2-103): 1.75e-09: 60.5: 14.73		NETB_DROME (14-231): 9.88e-45: 172: 21.52
+	Dm
		451766 NOTCH_DROME (8-205): 3.8e-09: 59.7: 19.74		NETB_DROME (14-231): 9.88e-45: 172: 21.52
+	Hs
		937387 NOTC2_HUMAN (6-246): 3.47e-10: 62.8: 21.52		LAMB2_HUMAN (330-607): 4.83e-14: 77.9: 18.44
+	Hs
		535835 NOTC2_HUMAN (6-246): 3.47e-10: 62.8: 21.52		LAMC1_HUMAN (228-391): 8.08e-11: 67.5: 14.02
+	Hs
		1047538 NOTC2_HUMAN (6-246): 3.47e-10: 62.8: 21.52		LAMB3_HUMAN (330-590): 2.85e-10: 65.6: 16.91
+	Dm
		262858 TENM_DROME (2-103): 1.75e-09: 60.5: 14.73		Q8IP51_DROME (214-399): 6.45e-11: 67.9: 13.44
+	Dm
		262790 TENM_DROME (2-103): 1.75e-09: 60.5: 14.73		NETA_DROME (330-483): 3.11e-10: 65.2: 23.98
+	Hs
		183243 NOTC2_HUMAN (6-246): 3.47e-10: 62.8: 21.52		LAMA5_HUMAN (205-397): 4.73e-09: 61.8: 16.04
+	Dm
		262765 TENM_DROME (2-103): 1.75e-09: 60.5: 14.73		LAMA_DROME (202-377): 1.27e-09: 63.7: 15.08
+	Dm
		451718 NOTCH_DROME (8-205): 3.8e-09: 59.7: 19.74		LAMC1_DROME (201-391): 6.82e-10: 64.5: 15.18
+	Dm
		451745 NOTCH_DROME (8-205): 3.8e-09: 59.7: 19.74		LAMA_DROME (202-377): 1.27e-09: 63.7: 15.08