HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: LAMB3 (Q13751)
Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta)
Gene: LAMB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2471 Hs			1 1172
+	Hs
		857423 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		NOTC1_HUMAN (124-481): 1.82e-28: 126: 12.97
+	Hs
		340703 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		NET1_HUMAN (431-676): 1.64e-25: 114: 19.39
+	Hs
		937387 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMB2_HUMAN (449-696): 1.85e-15: 84.1: 16.79
+	Hs
		535835 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMC1_HUMAN (143-376): 1.67e-11: 71: 14.47
+	Hs
		183243 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMA5_HUMAN (528-710): 7.26e-09: 62.6: 13.66
+	Dm
		95089 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		E1JHA6_DROME (326-708): 5.91e-21: 102: 12.90
+	Dm
		451718 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		LAMC1_DROME (431-688): 4e-17: 89.5: 18.55
+	Dm
		451745 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		LAMA_DROME (153-326): 9.39e-11: 68.7: 10.80
+	Dm
		451766 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		NETB_DROME (451-571): 5.23e-09: 62.8: 27.27
+	Hs
		1047634 ANR44_HUMAN (1522-2009): 3.15e-62: 235: 16.42		NOTC2_HUMAN (330-674): 4.36e-33: 141: 13.39
+	Hs
		857505 ANR44_HUMAN (1522-2009): 3.15e-62: 235: 16.42		NOTC1_HUMAN (124-481): 1.82e-28: 126: 12.97
+	Dm
		535775 Q0KIE7_DROME (1917-2288): 7.05e-60: 230: 16.35		LAMB1_DROME (432-673): 1.57e-14: 81: 16.05
+	Hs
		857370 NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26		NOTC1_HUMAN (124-481): 1.82e-28: 126: 12.97
+	Hs
		1008015 JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04		NOTC2_HUMAN (330-674): 4.36e-33: 141: 13.39
+	Hs
		857407 JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04		NOTC1_HUMAN (124-481): 1.82e-28: 126: 12.97
+	Hs
		1047784 JAG2_HUMAN (1175-1557): 7.17e-27: 122: 22.70		NOTC2_HUMAN (330-674): 4.36e-33: 141: 13.39
+	Hs
		857599 JAG2_HUMAN (1175-1557): 7.17e-27: 122: 22.70		NOTC1_HUMAN (124-481): 1.82e-28: 126: 12.97
+	Dr
		857368 Q1A5L2_DANRE (1346-1537): 7.25e-15: 83.4: 20.57		NOTC1_DANRE (124-481): 2.05e-33: 143: 12.41
+	Hs
		517113 NT2NC_HUMAN (1194-1404): 5.16e-17: 85.9: 33.92		NET4_HUMAN (449-659): 1.66e-20: 99.5: 19.49