HitPredict

Interactor 1: LAMC1 (P11047)
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
Gene: LAMC1

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1609 Hs			1 2471
+	Hs
		1047538 LAMB3_HUMAN (285-496): 9.72e-38: 157: 28.18		NOTC2_HUMAN (22-2471): 0: 1400: 100.00
+	Dm
		451718 LAMC1_DROME (15-1607): 0: 870: 38.24		NOTCH_DROME (2-871): 3.92e-108: 390: 32.69
+	Dm
		535775 LAMB1_DROME (45-1588): 3.56e-168: 556: 19.24		Q0KIE7_DROME (1917-2288): 7.05e-60: 230: 16.35
+	Dm
		68582 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		A8JNM5_DROME (1600-2294): 1.53e-111: 402: 12.07
+	Dm
		451712 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		NOTCH_DROME (2-871): 3.92e-108: 390: 32.69
+	Hs
		1047634 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		ANR44_HUMAN (1522-2009): 3.15e-62: 235: 16.42
+	Hs
		857505 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		ANR44_HUMAN (1522-2009): 3.15e-62: 235: 16.42
+	Hs
		857423 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		1008015 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04
+	Hs
		857370 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		857407 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04
+	Hs
		1047784 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		JAG2_HUMAN (1175-1557): 7.17e-27: 122: 22.70
+	Dm
		451716 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		DL_DROME (1175-1520): 2.25e-17: 91.3: 28.53
+	Hs
		857599 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		JAG2_HUMAN (1175-1557): 7.17e-27: 122: 22.70
+	Dm
		95089 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		E1JHA6_DROME (2-120): 7.36e-10: 67.3: 24.60
+	Dm
		451721 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		SERR_DROME (19-162): 5.24e-09: 64.1: 26.14
+	Hs
		772309 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		FBN2_HUMAN (1091-1658): 7.87e-11: 70.3: 13.74
+	Hs
		1047781 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		NOTC3_HUMAN (1931-2471): 1.32e-10: 69.6: 16.28
+	Hs
		857591 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		NOTC3_HUMAN (1931-2471): 1.32e-10: 69.6: 16.28