HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	15834155, 19380485
Identification Methods	pull down, affinity chromatography technology, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 864
+	Hs
		522862 SRC_HUMAN (1-536): 0: 651: 100.00		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		412090 FYN_HUMAN (1-536): 0: 598: 68.39		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		337437 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Hs
		412411 FYN_HUMAN (1-536): 0: 598: 68.39		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Hs
		442794 HCK_HUMAN (1-531): 0: 569: 55.22		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		411645 LCK_HUMAN (75-534): 0: 552: 58.48		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		433651 LYN_HUMAN (1-531): 0: 532: 52.44		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		337399 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		337597 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Ce
		220206 SRC2_CAEEL (24-534): 0: 520: 50.10		DYN1_CAEEL (3-805): 0: 916: 64.18
+	Ce
		106652 SRC1_CAEEL (1-534): 3.12e-176: 509: 49.08		DYN1_CAEEL (3-805): 0: 916: 64.18