HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SIK1 (P57059)
Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)
Gene: SIK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21985311
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019901 - protein kinase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 783
+	Hs
		529136 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK3_HUMAN (18-638): 7.04e-154: 468: 31.41
+	Hs
		530003 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK2_HUMAN (5-684): 4.27e-152: 465: 29.71
+	Hs
		530620 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SIK3_HUMAN (11-777): 1.05e-144: 460: 29.90
+	Hs
		530482 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK1_HUMAN (15-680): 3.46e-148: 455: 30.27
+	Hs
		530232 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK4_HUMAN (18-714): 4.05e-148: 453: 32.02
+	Hs
		536317 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK3_HUMAN (18-638): 7.04e-154: 468: 31.41
+	Hs
		536354 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK4_HUMAN (18-714): 4.05e-148: 453: 32.02
+	Hs
		698346 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		MARK4_HUMAN (18-714): 4.05e-148: 453: 32.02