HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SIK3 (Q9Y2K2)
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)
Gene: SIK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26402096
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1321
+	Hs
		529136 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK3_HUMAN (1-706): 5.66e-155: 487: 31.29
+	Hs
		530003 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK2_HUMAN (15-704): 8.01e-144: 458: 30.93
+	Hs
		530232 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK4_HUMAN (1-716): 1.71e-142: 453: 30.76
+	Hs
		529448 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SIK1_HUMAN (50-800): 7.05e-138: 442: 32.42
+	Hs
		529186 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT2_HUMAN (40-393): 2.94e-137: 430: 27.98
+	Hs
		530482 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK1_HUMAN (41-382): 1.93e-105: 354: 55.43
+	Hs
		536317 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK3_HUMAN (1-706): 5.66e-155: 487: 31.29
+	Hs
		536354 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK4_HUMAN (1-716): 1.71e-142: 453: 30.76
+	Hs
		530051 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		BRSK2_HUMAN (63-398): 9.47e-78: 275: 43.49
+	Hs
		698346 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		MARK4_HUMAN (1-716): 1.71e-142: 453: 30.76
+	Mm
		631788 MTAP2_MOUSE (26-758): 2.26e-30: 131: 24.41		BRSK2_MOUSE (63-398): 5.8e-78: 275: 43.49