HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DPYL3 (Q14195)
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)
Gene: DPYSL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding GO:0030426 - growth cone GO:0044297 - cell body
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 570
+	Hs
		529784 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		DPYL1_HUMAN (1-569): 0: 748: 74.43
+	Hs
		529881 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		DPYL2_HUMAN (1-569): 0: 742: 76.71
+	Hs
		155827 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		DPYL4_HUMAN (1-570): 0: 730: 70.11
+	Mm
		530837 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		DPYL3_MOUSE (1-570): 0: 764: 98.42
+	Rn
		620014 TAU_RAT (1-758): 3.21e-76: 263: 72.11		DPYL2_RAT (1-569): 0: 740: 77.41
+	Rn
		98706 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		DPYL2_RAT (1-569): 0: 740: 77.41
+	Rn
		620074 TAU_RAT (1-758): 3.21e-76: 263: 72.11		DPYL1_RAT (1-569): 0: 737: 74.26
+	Rn
		98766 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		DPYL1_RAT (1-569): 0: 737: 74.26
+	Hs
		530288 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		DPYL5_HUMAN (9-565): 0: 649: 50.71
+	Hs
		697624 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		PYR1_HUMAN (26-562): 1.22e-133: 431: 17.65