HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 920
+	Hs
		176360 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		243124 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		337320 ABL1_HUMAN (5-131): 2.58e-34: 127: 25.78		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		411564 LCK_HUMAN (3-127): 1.87e-34: 126: 25.19		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		433225 YES_HUMAN (3-125): 1.4e-34: 126: 23.26		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		442764 HCK_HUMAN (3-125): 2.65e-34: 126: 25.58		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487203 ABL2_HUMAN (5-131): 3.02e-34: 126: 25.00		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487245 BLK_HUMAN (5-125): 2.91e-34: 125: 24.60		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487088 SRC_HUMAN (3-125): 2.31e-33: 123: 25.58		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		368834 YES_HUMAN (3-125): 1.4e-34: 126: 23.26		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		368894 SRC_HUMAN (3-125): 2.31e-33: 123: 25.58		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Rn
		411266 SRC_RAT (3-125): 1.64e-33: 123: 25.58		ESR1_RAT (378-904): 2.19e-130: 406: 20.94
+	Mm
		403414 SRC_MOUSE (3-125): 2.23e-33: 123: 25.58		ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30
+	Hs
		377007 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		377006 LCK_HUMAN (3-127): 1.87e-34: 126: 25.19		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		377057 SRC_HUMAN (3-125): 2.31e-33: 123: 25.58		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		176481 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		433435 YES_HUMAN (3-125): 1.4e-34: 126: 23.26		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		414427 SRC_HUMAN (3-125): 2.31e-33: 123: 25.58		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		487890 SRC_HUMAN (3-125): 2.31e-33: 123: 25.58		RARA_HUMAN (460-902): 8.57e-110: 348: 19.87