HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: STK38 (Q15208)
Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)
Gene: STK38

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 465
+	Hs
		530617 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ST38L_HUMAN (11-465): 3.75e-179: 510: 87.47
+	Hs
		529185 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT1_HUMAN (36-447): 3.63e-138: 407: 27.29
+	Hs
		529186 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT2_HUMAN (6-447): 1.24e-137: 406: 24.45
+	Hs
		529026 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KAPCA_HUMAN (59-418): 6.99e-128: 376: 33.15
+	Hs
		529085 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KAPCB_HUMAN (74-418): 9.9e-128: 376: 34.29
+	Hs
		1144299 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		STK38_HUMAN (1-465): 0: 533: 100.00
+	Hs
		1401460 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		ST38L_HUMAN (11-465): 3.75e-179: 510: 87.47
+	Hs
		270762 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ROCK2_HUMAN (71-447): 2.17e-76: 261: 40.21
+	Hs
		536312 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		KAPCA_HUMAN (59-418): 6.99e-128: 376: 33.15
+	Hs
		536315 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		KAPCB_HUMAN (74-418): 9.9e-128: 376: 34.29
+	Hs
		161418 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		AKT1_HUMAN (36-447): 3.63e-138: 407: 27.29