HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31324722, 17110338
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032991 - protein-containing complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1748
+	Hs
		303741 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ZO3_HUMAN (13-915): 5.56e-135: 446: 38.65
+	Hs
		159147 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		529050 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		529855 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98