HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SMU1 (Q2TAY7)
WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]
Gene: SMU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 513
+	Hs
		530381 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		WDR26_HUMAN (3-513): 2.74e-90: 291: 19.12
+	Hs
		529281 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		LIS1_HUMAN (4-472): 1.83e-91: 286: 15.13
+	Hs
		1180246 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		SMU1_HUMAN (1-513): 1.62e-153: 449: 100.00
+	Hs
		1129749 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		WDR26_HUMAN (3-513): 2.74e-90: 291: 19.12
+	Hs
		529583 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		RACK1_HUMAN (277-377): 7.28e-11: 65.5: 33.33
+	Hs
		529555 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		GBB2_HUMAN (431-511): 1.7e-10: 64.5: 12.35
+	Hs
		698256 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		WDR5_HUMAN (78-425): 4.43e-77: 247: 20.96
+	Hs
		965173 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		WDR5_HUMAN (78-425): 4.43e-77: 247: 20.96
+	Hs
		161443 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		WDR5_HUMAN (78-425): 4.43e-77: 247: 20.96
+	Hs
		965097 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		WDR5_HUMAN (78-425): 4.43e-77: 247: 20.96
+	Mm
		965395 KMT2C_MOUSE (228-587): 6.08e-09: 61.9: 16.84		WDR5_MOUSE (78-425): 4.43e-77: 247: 20.96
+	Hs
		1129693 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		SNR40_HUMAN (51-333): 5.1e-39: 147: 14.34
+	Hs
		984123 SPEG_HUMAN (183-564): 2.89e-23: 108: 16.71		GBB2_HUMAN (431-511): 1.7e-10: 64.5: 12.35
+	Hs
		992751 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		RACK1_HUMAN (277-377): 7.28e-11: 65.5: 33.33
+	Hs
		161490 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		POC1A_HUMAN (438-513): 3.35e-19: 91.5: 19.74
+	Hs
		161486 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		WDR5B_HUMAN (427-512): 3.83e-18: 87.3: 22.09
+	Hs
		992919 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		RACK1_HUMAN (277-377): 7.28e-11: 65.5: 33.33