HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: MYO5B (Q9ULV0)
Unconventional myosin-Vb
Gene: MYO5B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	17462998, 29924966
Identification Methods	anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1848
+	Hs
		529959 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5A_HUMAN (1-1848): 0: 1157: 61.96
+	Hs
		529767 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5C_HUMAN (848-1848): 5.22e-71: 266: 28.40
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (726-1626): 6.98e-39: 162: 12.28
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (722-1504): 2.64e-32: 140: 10.15
+	Hs
		522533 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH1_HUMAN (833-1487): 4.69e-26: 119: 13.90
+	Hs
		529895 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH2_HUMAN (833-1453): 9.2e-25: 115: 13.39
+	Hs
		528400 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH8_HUMAN (806-1396): 4.48e-24: 113: 13.93
+	Hs
		529972 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH4_HUMAN (827-1399): 1.31e-23: 111: 13.35
+	Hs
		502902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH3_HUMAN (809-1414): 2.77e-23: 110: 12.69