HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TTBK1 (Q5TCY1)
Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase)
Gene: TTBK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16923168
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007611 - learning or memory GO:0010629 - negative regulation of gene expression and 1 others more... GO:0043025 - neuronal cell body
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1321
+	Hs
		270762 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ROCK2_HUMAN (28-1037): 3.32e-147: 484: 12.49
+	Hs
		529136 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK3_HUMAN (7-752): 3.27e-131: 423: 14.53
+	Hs
		530546 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		TNIK_HUMAN (34-914): 9.66e-123: 415: 12.82
+	Hs
		530012 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		TAOK1_HUMAN (8-986): 2.17e-124: 412: 14.03
+	Hs
		530003 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK2_HUMAN (4-692): 4.8e-122: 400: 16.62
+	Hs
		530482 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK1_HUMAN (8-716): 1.6e-116: 385: 15.83
+	Hs
		529326 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KC1D_HUMAN (26-448): 1.72e-116: 372: 30.70
+	Hs
		529325 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KC1A_HUMAN (20-348): 7.36e-116: 367: 31.55
+	Hs
		536317 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK3_HUMAN (7-752): 3.27e-131: 423: 14.53
+	Hs
		1461071 PCLO_HUMAN (21-757): 4.9e-30: 130: 10.00		TNIK_HUMAN (34-914): 9.66e-123: 415: 12.82
+	Rn
		1055381 MAP4_RAT (56-743): 4.09e-10: 65.4: 9.01		KC1D_RAT (26-447): 3.91e-121: 384: 30.54