HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1360
+	Hs
		1461071 PCLO_HUMAN (21-757): 4.9e-30: 130: 10.00		TNIK_HUMAN (1-1360): 0: 1245: 100.00
+	Hs
		348042 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		M4K4_HUMAN (1-1360): 0: 986: 59.18
+	Hs
		529382 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KS6A3_HUMAN (10-701): 2e-134: 432: 16.97
+	Hs
		530620 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SIK3_HUMAN (7-955): 8.52e-126: 424: 14.88
+	Hs
		529136 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK3_HUMAN (3-677): 1.49e-126: 412: 16.50
+	Hs
		530232 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK4_HUMAN (7-748): 5.41e-123: 402: 18.00
+	Hs
		529186 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT2_HUMAN (3-352): 1.1e-123: 394: 22.87
+	Hs
		530012 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		TAOK1_HUMAN (1-632): 3.43e-109: 371: 27.37
+	Hs
		530683 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		STK24_HUMAN (20-340): 1.99e-111: 360: 43.03
+	Hs
		529850 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KS6A1_HUMAN (1-350): 9.43e-97: 329: 22.68
+	Mm
		693429 MAP4_MOUSE (11-720): 3.02e-34: 143: 17.29		TAOK2_MOUSE (1-858): 7.78e-132: 439: 22.25
+	Mm
		631791 MTAP2_MOUSE (26-758): 2.26e-30: 131: 24.41		TAOK2_MOUSE (1-858): 7.78e-132: 439: 22.25
+	Hs
		536317 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK3_HUMAN (3-677): 1.49e-126: 412: 16.50
+	Hs
		536354 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK4_HUMAN (7-748): 5.41e-123: 402: 18.00
+	Hs
		1129782 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		KS6A6_HUMAN (10-709): 1.65e-130: 422: 16.27
+	Hs
		1401442 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		TAOK2_HUMAN (1-861): 1.2e-130: 436: 22.29
+	Hs
		698346 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		MARK4_HUMAN (7-748): 5.41e-123: 402: 18.00