HitPredict

Interactor 1: ITA4 (P13612)
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Gene: ITGA4

Interactor 2: VCAM1 (P19320)
Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Gene: VCAM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

The method score is based on:

Property	Details
Experiments	19738201, 22623428
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0007159 - leukocyte cell-cell adhesion GO:0007160 - cell-matrix adhesion GO:0009897 - external side of plasma membrane and 8 others more... GO:0009986 - cell surface GO:0030183 - B cell differentiation GO:0034113 - heterotypic cell-cell adhesion GO:0050839 - cell adhesion molecule binding GO:0050901 - leukocyte tethering or rolling GO:0070062 - extracellular exosome GO:0140039 - cell-cell adhesion in response to extracellular stimulus GO:1904646 - cellular response to amyloid-beta
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	1032
Hs

1	739

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024