HitPredict

Interactor 1: THB (P10828)
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene: THRB

Interactor 2: BRD8 (Q9H0E9)
Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)
Gene: BRD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	9368056
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0097067 - cellular response to thyroid hormone stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 461 Hs			1 1235
+	Hs
		625844 RXRA_HUMAN (19-460): 4.49e-117: 352: 22.49		BRD8_HUMAN (1-1235): 0: 590: 100.00
+	Hs
		396909 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		BRD8_HUMAN (1-1235): 0: 590: 100.00
+	Mm
		74262 THB_MOUSE (1-461): 4.38e-149: 434: 96.53		EP300_MOUSE (807-1211): 5.16e-30: 131: 15.12
+	Mm
		704497 RXRA_MOUSE (17-460): 1.32e-118: 356: 22.17		TIF1A_MOUSE (846-1224): 3.15e-32: 138: 14.00
+	Dm
		72168 ECR_DROME (76-460): 2.67e-109: 344: 29.54		A8WHL4_DROME (774-1225): 5.48e-36: 150: 14.59
+	Mm
		74253 RARB_MOUSE (3-461): 9.25e-120: 360: 30.67		EP300_MOUSE (807-1211): 5.16e-30: 131: 15.12
+	Hs
		180700 RXRA_HUMAN (19-460): 4.49e-117: 352: 22.49		TIF1A_HUMAN (846-1228): 2.48e-31: 135: 14.11
+	Hs
		180651 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		TIF1A_HUMAN (846-1228): 2.48e-31: 135: 14.11
+	Hs
		397007 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		BRD7_HUMAN (1039-1212): 6.56e-29: 126: 17.32
+	Hs
		396428 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		PB1_HUMAN (988-1226): 1.68e-22: 107: 15.51
+	Hs
		625785 RXRA_HUMAN (19-460): 4.49e-117: 352: 22.49		SMCA4_HUMAN (1057-1208): 7.29e-19: 95.5: 13.84
+	Hs
		396483 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		TAF1L_HUMAN (1101-1206): 4.27e-19: 96.3: 21.70
+	Hs
		395720 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		SMCA4_HUMAN (1057-1208): 7.29e-19: 95.5: 13.84
+	Dm
		121976 ECR_DROME (76-460): 2.67e-109: 344: 29.54		M9PH39_DROME (622-802): 6.17e-14: 79.5: 23.28
+	Hs
		625836 RXRA_HUMAN (19-460): 4.49e-117: 352: 22.49		CBP_HUMAN (105-563): 8.91e-10: 65.7: 7.96
+	Hs
		396647 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		KAT2A_HUMAN (684-810): 1.1e-12: 74.9: 17.32
+	Hs
		625801 RXRA_HUMAN (19-460): 4.49e-117: 352: 22.49		EP300_HUMAN (150-707): 9.24e-09: 62.4: 8.45
+	Mm
		107054 RXRG_MOUSE (2-460): 3.89e-113: 342: 20.82		F8VPR5_MOUSE (105-556): 1.3e-10: 68.4: 9.87
+	Hs
		396643 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		CBP_HUMAN (105-563): 8.91e-10: 65.7: 7.96
+	Hs
		395991 ESR1_HUMAN (8-460): 1.88e-111: 342: 18.66		EP300_HUMAN (150-707): 9.24e-09: 62.4: 8.45