HitPredict

Interactor 1: ACT (P10989)
Actin (EC 3.6.4.-)
Gene: act1

Interactor 2: COFI (P78929)
Cofilin (Actin-depolymerizing factor 1)
Gene: cof1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	21148484, 21723825, 28282023, 22024167
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0015629 - actin cytoskeleton GO:0030479 - actin cortical patch GO:0032153 - cell division site GO:0051286 - cell tip
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Sp			1 137
+	At
		509991 ACT1_ARATH (3-375): 0: 701: 87.94		ADF4_ARATH (2-135): 3.31e-55: 170: 38.97
+	At
		509990 ACT1_ARATH (3-375): 0: 701: 87.94		ADF6_ARATH (2-135): 1.57e-53: 167: 44.85
+	At
		509993 ACT3_ARATH (3-375): 0: 701: 87.94		ADF6_ARATH (2-135): 1.57e-53: 167: 44.85
+	Hs
		952697 ACTB_HUMAN (1-375): 0: 598: 90.40		DEST_HUMAN (3-134): 4.3e-47: 151: 33.78
+	Hs
		955818 ACTG_HUMAN (1-375): 0: 598: 91.47		DEST_HUMAN (3-134): 4.3e-47: 151: 33.78
+	Hs
		955834 Q1KLZ0_HUMAN (1-375): 0: 598: 90.40		DEST_HUMAN (3-134): 4.3e-47: 151: 33.78
+	Hs
		660017 ACTB_HUMAN (1-375): 0: 598: 90.40		COF1_HUMAN (3-134): 1.17e-45: 147: 33.55
+	Hs
		660028 ACTG_HUMAN (1-375): 0: 598: 91.47		COF1_HUMAN (3-134): 1.17e-45: 147: 33.55
+	Hs
		660081 Q1KLZ0_HUMAN (1-375): 0: 598: 90.40		COF1_HUMAN (3-134): 1.17e-45: 147: 33.55
+	Hs
		1168811 Q1KLZ0_HUMAN (1-375): 0: 598: 90.40		Q549N0_HUMAN (3-134): 4.25e-45: 146: 32.24
+	Hs
		952874 ACTB_HUMAN (1-375): 0: 598: 90.40		Q549N0_HUMAN (3-134): 4.25e-45: 146: 32.24
+	Hs
		953195 ACTB_HUMAN (1-375): 0: 598: 90.40		COF2_HUMAN (3-134): 4.25e-45: 146: 32.24
+	Hs
		993207 ACTG_HUMAN (1-375): 0: 598: 91.47		Q549N0_HUMAN (3-134): 4.25e-45: 146: 32.24
+	Hs
		993390 ACTG_HUMAN (1-375): 0: 598: 91.47		COF2_HUMAN (3-134): 4.25e-45: 146: 32.24
+	Hs
		952698 ACTB_HUMAN (1-375): 0: 598: 90.40		GMFB_HUMAN (8-134): 1.13e-36: 123: 19.70
+	Hs
		955875 ACTG_HUMAN (1-375): 0: 598: 91.47		GMFB_HUMAN (8-134): 1.13e-36: 123: 19.70
+	Hs
		952893 ACTB_HUMAN (1-375): 0: 598: 90.40		TWF2_HUMAN (10-137): 2.64e-18: 80.8: 23.13
+	Hs
		993215 ACTG_HUMAN (1-375): 0: 598: 91.47		TWF2_HUMAN (10-137): 2.64e-18: 80.8: 23.13
+	Hs
		952782 ACTB_HUMAN (1-375): 0: 598: 90.40		TWF1_HUMAN (8-137): 8.59e-18: 79.6: 21.32
+	Hs
		993148 ACTG_HUMAN (1-375): 0: 598: 91.47		TWF1_HUMAN (8-137): 8.59e-18: 79.6: 21.32