HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: Q1KLZ0 (Q1KLZ0)
HCG15971, isoform CRA_a (PS1TP5-binding protein 1)
Gene: PS1TP5BP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 375
+	Hs
		660089 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Mm
		616470 COF1_MOUSE (1-166): 1.36e-72: 217: 98.80		ACTB_MOUSE (1-375): 0: 603: 100.00
+	Rn
		852477 COF1_RAT (1-166): 3.12e-72: 216: 99.40		ACTB_RAT (1-375): 0: 603: 100.00
+	Hs
		660017 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		1168811 Q549N0_HUMAN (1-166): 1.69e-71: 214: 80.72		Q1KLZ0_HUMAN (1-375): 0: 603: 100.00
+	Hs
		952874 Q549N0_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		953195 COF2_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		660028 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		993207 Q549N0_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		993390 COF2_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		952697 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		955834 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		Q1KLZ0_HUMAN (1-375): 0: 603: 100.00
+	Hs
		955818 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		660031 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		660032 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		660025 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		995907 COF2_HUMAN (1-166): 1.69e-71: 214: 80.72		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		660029 COF1_HUMAN (1-166): 4.48e-72: 215: 100.00		ACTH_HUMAN (2-375): 0: 589: 93.58
+	Hs
		955819 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		955817 DEST_HUMAN (1-166): 3.72e-69: 208: 71.08		ACTA_HUMAN (2-375): 0: 591: 94.12