HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: STIP1 (P31948)
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Gene: STIP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	35271311, 33239621, 38334954, 31839598, 23938469, 9774640, 25864199, 10567422, 11093761
Identification Methods	affinity chromatography technology, cross-linking study, two hybrid, pull down, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HSP70~TPR_11, HSP70~TPR_12, HSP70~TPR_8
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0101031 - protein folding chaperone complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 543
+	Hs
		731003 HS71L_HUMAN (2-646): 0: 964: 82.48		STIP1_HUMAN (1-543): 2.06e-97: 307: 100.00
+	Hs
		600747 HSP76_HUMAN (6-646): 0: 954: 77.54		STIP1_HUMAN (1-543): 2.06e-97: 307: 100.00
+	Hs
		516183 HS71B_HUMAN (1-646): 0: 946: 84.37		STIP1_HUMAN (1-543): 2.06e-97: 307: 100.00
+	Hs
		731123 HSP72_HUMAN (2-646): 0: 938: 85.47		STIP1_HUMAN (1-543): 2.06e-97: 307: 100.00
+	At
		1441393 HS704_ARATH (3-646): 0: 946: 76.35		HSOP1_ARATH (3-543): 1.42e-93: 298: 41.78
+	Hs
		537771 HSP7C_HUMAN (1-646): 0: 966: 100.00		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		600897 HSP76_HUMAN (6-646): 0: 954: 77.54		SGTB_HUMAN (213-348): 5.7e-32: 126: 31.39
+	Hs
		1198774 Q53FA3_HUMAN (2-646): 0: 965: 82.33		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		761494 HS71L_HUMAN (2-646): 0: 964: 82.48		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		600911 HSP76_HUMAN (6-646): 0: 954: 77.54		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		761411 HS71L_HUMAN (2-646): 0: 964: 82.48		TOM34_HUMAN (1-119): 8.16e-23: 100: 26.05
+	Hs
		516174 HS71A_HUMAN (1-646): 0: 946: 84.37		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		516209 HS71B_HUMAN (1-646): 0: 946: 84.37		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		185383 HSP7C_HUMAN (1-646): 0: 966: 100.00		OGT1_HUMAN (5-241): 5.34e-17: 86.9: 12.24
+	Hs
		931079 HSP72_HUMAN (2-646): 0: 938: 85.47		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		600938 HSP76_HUMAN (6-646): 0: 954: 77.54		RPAP3_HUMAN (2-129): 4.51e-20: 96.2: 28.91
+	Hs
		317978 HSP7C_HUMAN (1-646): 0: 966: 100.00		TOM70_HUMAN (216-543): 8.73e-13: 73.1: 10.73
+	Mm
		989266 HSP7C_MOUSE (1-646): 0: 965: 99.85		SGTA_MOUSE (202-327): 4.18e-10: 63.2: 33.33
+	Hs
		226689 HSP7C_HUMAN (1-646): 0: 966: 100.00		SGTA_HUMAN (202-327): 4e-09: 60.1: 32.54
+	Hs
		930860 HSP72_HUMAN (2-646): 0: 938: 85.47		SPAG1_HUMAN (405-527): 2.23e-10: 65.3: 14.63