HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1297 Hs			1 889
+	Hs
		435752 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		411491 INSR_HUMAN (27-1288): 0: 1183: 52.18		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		537772 INSRR_HUMAN (1-1297): 0: 1365: 100.00		OSBL5_HUMAN (32-889): 0: 1012: 54.21
+	Hs
		665522 EPHA8_HUMAN (454-1268): 2.42e-179: 558: 20.16		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		435736 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		435750 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		1318012 ALK_HUMAN (946-1247): 1.07e-70: 263: 43.46		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		385477 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		1081595 NTRK3_HUMAN (957-1242): 2.05e-62: 231: 40.84		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		508182 FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		445877 ROS1_HUMAN (764-900): 8.58e-11: 68.9: 22.63		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		665524 EPHA8_HUMAN (454-1268): 2.42e-179: 558: 20.16		OSBL2_HUMAN (323-758): 4.85e-138: 421: 23.19
+	Hs
		385387 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		508159 FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		384259 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42
+	Hs
		603057 NTRK3_HUMAN (957-1242): 2.05e-62: 231: 40.84		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42
+	Hs
		385465 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		508177 FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62