HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 768
+	Hs
		438152 HS90B_HUMAN (75-783): 0: 997: 46.54		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		431831 HS90A_HUMAN (60-783): 0: 990: 45.34		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		538227 ENPL_HUMAN (1-803): 0: 1073: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		538228 ENPL_HUMAN (1-803): 0: 1073: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		438153 HS90B_HUMAN (75-783): 0: 997: 46.54		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		431832 HS90A_HUMAN (60-783): 0: 990: 45.34		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		538224 ENPL_HUMAN (1-803): 0: 1073: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		438154 HS90B_HUMAN (75-783): 0: 997: 46.54		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		431833 HS90A_HUMAN (60-783): 0: 990: 45.34		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		538225 ENPL_HUMAN (1-803): 0: 1073: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		438150 HS90B_HUMAN (75-783): 0: 997: 46.54		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		431829 HS90A_HUMAN (60-783): 0: 990: 45.34		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		538342 ENPL_HUMAN (1-803): 0: 1073: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		438151 HS90B_HUMAN (75-783): 0: 997: 46.54		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		431830 HS90A_HUMAN (60-783): 0: 990: 45.34		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		438412 HS90B_HUMAN (75-783): 0: 997: 46.54		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		432131 HS90A_HUMAN (60-783): 0: 990: 45.34		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		1041724 ENPLL_HUMAN (352-803): 0: 578: 76.82		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Sc
		544559 HSC82_YEAST (72-783): 0: 869: 47.57		CDC53_YEAST (30-768): 0: 573: 22.08
+	Sc
		367047 HSP82_YEAST (72-783): 0: 867: 47.17		CDC53_YEAST (30-768): 0: 573: 22.08