HitPredict

Interactor 1: PYC (P11498)
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)
Gene: PC

Interactor 2: SAR1B (Q9Y6B6)
Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B)
Gene: SAR1B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35844135
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1178 Hs			1 198
+	Hs
		547129 PYC_HUMAN (1-1178): 0: 1462: 100.00		ARF5_HUMAN (10-197): 2.09e-74: 223: 27.66
+	Hs
		547087 PYC_HUMAN (1-1178): 0: 1462: 100.00		ARF4_HUMAN (10-197): 8.67e-74: 221: 27.66
+	Hs
		547210 PYC_HUMAN (1-1178): 0: 1462: 100.00		SAR1A_HUMAN (1-198): 5.13e-63: 195: 89.90
+	Hs
		547123 PYC_HUMAN (1-1178): 0: 1462: 100.00		ARF3_HUMAN (1-197): 3.85e-60: 187: 26.90
+	Hs
		1015009 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		ARF5_HUMAN (10-197): 2.09e-74: 223: 27.66
+	Hs
		612209 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		ARF4_HUMAN (10-197): 8.67e-74: 221: 27.66
+	Hs
		144227 ACACB_HUMAN (1-742): 5.51e-175: 572: 23.27		ARF4_HUMAN (10-197): 8.67e-74: 221: 27.66
+	Hs
		1094288 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		SAR1B_HUMAN (1-198): 3.43e-64: 198: 100.00
+	Hs
		144338 ACACB_HUMAN (1-742): 5.51e-175: 572: 23.27		SAR1B_HUMAN (1-198): 3.43e-64: 198: 100.00
+	Hs
		1094270 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		SAR1A_HUMAN (1-198): 5.13e-63: 195: 89.90
+	Sc
		453412 PYR1_YEAST (19-420): 2.79e-58: 223: 16.83		ARF2_YEAST (10-197): 3e-76: 228: 26.60
+	Hs
		425796 PCCA_HUMAN (1065-1178): 1.27e-34: 144: 30.44		ARF5_HUMAN (10-197): 2.09e-74: 223: 27.66
+	Hs
		425767 PCCA_HUMAN (1065-1178): 1.27e-34: 144: 30.44		ARF4_HUMAN (10-197): 8.67e-74: 221: 27.66
+	Hs
		1015095 MCCA_HUMAN (1085-1178): 3.54e-27: 121: 29.00		ARF5_HUMAN (10-197): 2.09e-74: 223: 27.66
+	Hs
		425869 PCCA_HUMAN (1065-1178): 1.27e-34: 144: 30.44		SAR1B_HUMAN (1-198): 3.43e-64: 198: 100.00
+	Hs
		612287 MCCA_HUMAN (1085-1178): 3.54e-27: 121: 29.00		ARF4_HUMAN (10-197): 8.67e-74: 221: 27.66
+	Hs
		425851 PCCA_HUMAN (1065-1178): 1.27e-34: 144: 30.44		SAR1A_HUMAN (1-198): 5.13e-63: 195: 89.90
+	Hs
		1401790 MCCA_HUMAN (1085-1178): 3.54e-27: 121: 29.00		SAR1B_HUMAN (1-198): 3.43e-64: 198: 100.00
+	Hs
		1401766 MCCA_HUMAN (1085-1178): 3.54e-27: 121: 29.00		SAR1A_HUMAN (1-198): 5.13e-63: 195: 89.90
+	Hs
		1014946 MCCA_HUMAN (1085-1178): 3.54e-27: 121: 29.00		ARF1_HUMAN (1-197): 2.04e-60: 188: 26.90