HitPredict

Interactor 1: TPR (P12270)
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)
Gene: TPR

Interactor 2: RIF1 (Q5UIP0)
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
Gene: RIF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	40437099
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0031965 - nuclear membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2363 Hs			1 2472
+	Hs
		1134610 NUMA1_HUMAN (1303-2072): 5.22e-17: 90.5: 10.52		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		157488 CTRO_HUMAN (1173-1646): 8.17e-09: 63.5: 22.34		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		552850 TPR_HUMAN (1-2351): 1.51e-168: 578: 100.00		TITIN_HUMAN (1353-2455): 8.62e-10: 66.9: 8.12
+	Hs
		773158 MYH10_HUMAN (415-1520): 5.44e-42: 172: 11.65		ANK2_HUMAN (1292-2406): 3.37e-18: 94.9: 9.95
+	Hs
		772661 MYH9_HUMAN (696-1621): 3.36e-09: 64.7: 18.74		MAP1B_HUMAN (925-2416): 3.36e-43: 177: 10.23
+	Hs
		1035528 CENPE_HUMAN (825-2321): 3.81e-42: 173: 9.68		TITIN_HUMAN (1353-2455): 8.62e-10: 66.9: 8.12
+	Hs
		587716 DESP_HUMAN (688-1584): 5.97e-11: 70.5: 18.36		CNTRL_HUMAN (924-2161): 1.92e-36: 154: 10.94
+	Hs
		157556 CTRO_HUMAN (1173-1646): 8.17e-09: 63.5: 22.34		RBBP6_HUMAN (1213-2173): 5.47e-27: 123: 9.31
+	Hs
		1129593 NUMA1_HUMAN (1303-2072): 5.22e-17: 90.5: 10.52		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		158047 CTRO_HUMAN (1173-1646): 8.17e-09: 63.5: 22.34		PCLO_HUMAN (1455-2432): 2.53e-20: 101: 6.54
+	Hs
		157501 CTRO_HUMAN (1173-1646): 8.17e-09: 63.5: 22.34		NIPBL_HUMAN (948-1837): 3.17e-19: 98.1: 12.40
+	Hs
		772749 MYH9_HUMAN (696-1621): 3.36e-09: 64.7: 18.74		ANK2_HUMAN (1292-2406): 3.37e-18: 94.9: 9.95
+	Hs
		157378 CTRO_HUMAN (1173-1646): 8.17e-09: 63.5: 22.34		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		587751 DESP_HUMAN (688-1584): 5.97e-11: 70.5: 18.36		TITIN_HUMAN (1353-2455): 8.62e-10: 66.9: 8.12
+	Hs
		772931 MYH9_HUMAN (696-1621): 3.36e-09: 64.7: 18.74		TITIN_HUMAN (1353-2455): 8.62e-10: 66.9: 8.12
+	Hs
		157606 CTRO_HUMAN (1173-1646): 8.17e-09: 63.5: 22.34		CMYA5_HUMAN (1140-2297): 2.12e-09: 65.8: 11.63